Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults

Daniel Gagnon, Steven A. Romero, Hai Ngo, Satyam Sarma, William K. Cornwell, Paula Y.S. Poh, Douglas Stoller, Benjamin D. Levine, Craig G. Crandall

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Key points: Age-related changes in cutaneous microvascular and cardiac functions limit the extent of cutaneous vasodilatation and the increase in cardiac output that healthy older adults can achieve during passive heat stress. However, it is unclear if these age-related changes in microvascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and cardiac output that healthy older adults can achieve during heat stress. We observed that rapid volume loading, performed during passive heat stress, augments both cutaneous vasodilatation and cardiac output in healthy older humans. These findings demonstrate that the microcirculation of healthy aged skin can further dilate during passive heat exposure, despite peripheral limitations to vasodilatation. Furthermore, healthy older humans can augment cardiac output when cardiac pre-load is increased during heat stress. Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 years) and ten older (O: 69 ± 3 years) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg-1, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min-1), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL (100 mL min-1 mmHg-1)-1), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg-1) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min-1), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL (100 mL min-1 mmHg-1)-1), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg-1) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.

Original languageEnglish (US)
JournalJournal of Physiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Vasodilation
Cardiac Output
Hot Temperature
Skin
Heating
Blood Vessels
Thermodilution
Plethysmography
Microcirculation
Forearm
Young Adult
Lasers
Temperature

Keywords

  • Ageing
  • Cardiac output
  • Skin blood flow
  • Sweat
  • Temperature
  • Vasodilatation

ASJC Scopus subject areas

  • Physiology

Cite this

Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults. / Gagnon, Daniel; Romero, Steven A.; Ngo, Hai; Sarma, Satyam; Cornwell, William K.; Poh, Paula Y.S.; Stoller, Douglas; Levine, Benjamin D.; Crandall, Craig G.

In: Journal of Physiology, 2017.

Research output: Contribution to journalArticle

Gagnon, Daniel ; Romero, Steven A. ; Ngo, Hai ; Sarma, Satyam ; Cornwell, William K. ; Poh, Paula Y.S. ; Stoller, Douglas ; Levine, Benjamin D. ; Crandall, Craig G. / Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults. In: Journal of Physiology. 2017.
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T1 - Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults

AU - Gagnon, Daniel

AU - Romero, Steven A.

AU - Ngo, Hai

AU - Sarma, Satyam

AU - Cornwell, William K.

AU - Poh, Paula Y.S.

AU - Stoller, Douglas

AU - Levine, Benjamin D.

AU - Crandall, Craig G.

PY - 2017

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N2 - Key points: Age-related changes in cutaneous microvascular and cardiac functions limit the extent of cutaneous vasodilatation and the increase in cardiac output that healthy older adults can achieve during passive heat stress. However, it is unclear if these age-related changes in microvascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and cardiac output that healthy older adults can achieve during heat stress. We observed that rapid volume loading, performed during passive heat stress, augments both cutaneous vasodilatation and cardiac output in healthy older humans. These findings demonstrate that the microcirculation of healthy aged skin can further dilate during passive heat exposure, despite peripheral limitations to vasodilatation. Furthermore, healthy older humans can augment cardiac output when cardiac pre-load is increased during heat stress. Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 years) and ten older (O: 69 ± 3 years) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg-1, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min-1), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL (100 mL min-1 mmHg-1)-1), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg-1) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min-1), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL (100 mL min-1 mmHg-1)-1), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg-1) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.

AB - Key points: Age-related changes in cutaneous microvascular and cardiac functions limit the extent of cutaneous vasodilatation and the increase in cardiac output that healthy older adults can achieve during passive heat stress. However, it is unclear if these age-related changes in microvascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and cardiac output that healthy older adults can achieve during heat stress. We observed that rapid volume loading, performed during passive heat stress, augments both cutaneous vasodilatation and cardiac output in healthy older humans. These findings demonstrate that the microcirculation of healthy aged skin can further dilate during passive heat exposure, despite peripheral limitations to vasodilatation. Furthermore, healthy older humans can augment cardiac output when cardiac pre-load is increased during heat stress. Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 years) and ten older (O: 69 ± 3 years) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg-1, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min-1), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL (100 mL min-1 mmHg-1)-1), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg-1) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min-1), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL (100 mL min-1 mmHg-1)-1), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg-1) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.

KW - Ageing

KW - Cardiac output

KW - Skin blood flow

KW - Sweat

KW - Temperature

KW - Vasodilatation

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