Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition

Philip M. Robson, Ananth J. Madhuranthakam, Martin P. Smith, Maryellen R M Sun, Weiying Dai, Neil M. Rofsky, Ivan Pedrosa, David C. Alsop

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rationale and Objectives: Renal perfusion measurements using noninvasive arterial spin-labeled (ASL) magnetic resonance imaging techniques are gaining interest. Currently, focus has been on perfusion in the context of renal transplant. Our objectives were to explore the use of ASL in patients with renal cancer, and to evaluate three-dimensional (3D) fast spin echo (FSE) acquisition, a robust volumetric imaging method for abdominal applications. We evaluate 3D ASL perfusion magnetic resonance imaging in the kidneys compared to two-dimensional (2D) ASL in patients and healthy subjects. Materials and Methods: Isotropic resolution (2.6 × 2.6 × 2.8 mm3) 3D ASL using segmented FSE was compared to 2D single-shot FSE. ASL used pseudo-continuous labeling, suppression of background signal, and synchronized breathing. Quantitative perfusion values and signal-to-noise ratio (SNR) were compared between 3D and 2D ASL in four healthy volunteers and semiquantitative assessments were made by four radiologists in four patients with known renal masses (primary renal cell carcinoma). Results: Renal cortex perfusion in healthy subjects was 284 ± 21 mL/100 g/min, with test-retest repeatability of 8.8%. No significant differences were found between the quantitative perfusion value and SNR in volunteers between 3D ASL and 2D ASL, or in 3D ASL with synchronized or free breathing. In patients, semiquantitative assessment by radiologists showed no significant difference in image quality between 2D ASL and 3D ASL. In one case, 2D ASL missed a high perfusion focus in a mass that was seen by 3D ASL. Conclusions: 3D ASL renal perfusion imaging provides isotropic-resolution images, with comparable quantitative perfusion values and image SNR in similar imaging time to single-slice 2D ASL.

Original languageEnglish (US)
Pages (from-to)144-154
Number of pages11
JournalAcademic Radiology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Perfusion Imaging
Perfusion
Kidney
Signal-To-Noise Ratio
Healthy Volunteers
Respiration
Kidney Neoplasms
Magnetic Resonance Angiography
Renal Cell Carcinoma
Volunteers
Magnetic Resonance Imaging
Transplants

Keywords

  • Arterial spin labeling
  • Blood flow
  • Kidney disease
  • MRI
  • Perfusion
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition. / Robson, Philip M.; Madhuranthakam, Ananth J.; Smith, Martin P.; Sun, Maryellen R M; Dai, Weiying; Rofsky, Neil M.; Pedrosa, Ivan; Alsop, David C.

In: Academic Radiology, Vol. 23, No. 2, 01.02.2016, p. 144-154.

Research output: Contribution to journalArticle

Robson, Philip M. ; Madhuranthakam, Ananth J. ; Smith, Martin P. ; Sun, Maryellen R M ; Dai, Weiying ; Rofsky, Neil M. ; Pedrosa, Ivan ; Alsop, David C. / Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition. In: Academic Radiology. 2016 ; Vol. 23, No. 2. pp. 144-154.
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abstract = "Rationale and Objectives: Renal perfusion measurements using noninvasive arterial spin-labeled (ASL) magnetic resonance imaging techniques are gaining interest. Currently, focus has been on perfusion in the context of renal transplant. Our objectives were to explore the use of ASL in patients with renal cancer, and to evaluate three-dimensional (3D) fast spin echo (FSE) acquisition, a robust volumetric imaging method for abdominal applications. We evaluate 3D ASL perfusion magnetic resonance imaging in the kidneys compared to two-dimensional (2D) ASL in patients and healthy subjects. Materials and Methods: Isotropic resolution (2.6 × 2.6 × 2.8 mm3) 3D ASL using segmented FSE was compared to 2D single-shot FSE. ASL used pseudo-continuous labeling, suppression of background signal, and synchronized breathing. Quantitative perfusion values and signal-to-noise ratio (SNR) were compared between 3D and 2D ASL in four healthy volunteers and semiquantitative assessments were made by four radiologists in four patients with known renal masses (primary renal cell carcinoma). Results: Renal cortex perfusion in healthy subjects was 284 ± 21 mL/100 g/min, with test-retest repeatability of 8.8{\%}. No significant differences were found between the quantitative perfusion value and SNR in volunteers between 3D ASL and 2D ASL, or in 3D ASL with synchronized or free breathing. In patients, semiquantitative assessment by radiologists showed no significant difference in image quality between 2D ASL and 3D ASL. In one case, 2D ASL missed a high perfusion focus in a mass that was seen by 3D ASL. Conclusions: 3D ASL renal perfusion imaging provides isotropic-resolution images, with comparable quantitative perfusion values and image SNR in similar imaging time to single-slice 2D ASL.",
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AU - Smith, Martin P.

AU - Sun, Maryellen R M

AU - Dai, Weiying

AU - Rofsky, Neil M.

AU - Pedrosa, Ivan

AU - Alsop, David C.

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AB - Rationale and Objectives: Renal perfusion measurements using noninvasive arterial spin-labeled (ASL) magnetic resonance imaging techniques are gaining interest. Currently, focus has been on perfusion in the context of renal transplant. Our objectives were to explore the use of ASL in patients with renal cancer, and to evaluate three-dimensional (3D) fast spin echo (FSE) acquisition, a robust volumetric imaging method for abdominal applications. We evaluate 3D ASL perfusion magnetic resonance imaging in the kidneys compared to two-dimensional (2D) ASL in patients and healthy subjects. Materials and Methods: Isotropic resolution (2.6 × 2.6 × 2.8 mm3) 3D ASL using segmented FSE was compared to 2D single-shot FSE. ASL used pseudo-continuous labeling, suppression of background signal, and synchronized breathing. Quantitative perfusion values and signal-to-noise ratio (SNR) were compared between 3D and 2D ASL in four healthy volunteers and semiquantitative assessments were made by four radiologists in four patients with known renal masses (primary renal cell carcinoma). Results: Renal cortex perfusion in healthy subjects was 284 ± 21 mL/100 g/min, with test-retest repeatability of 8.8%. No significant differences were found between the quantitative perfusion value and SNR in volunteers between 3D ASL and 2D ASL, or in 3D ASL with synchronized or free breathing. In patients, semiquantitative assessment by radiologists showed no significant difference in image quality between 2D ASL and 3D ASL. In one case, 2D ASL missed a high perfusion focus in a mass that was seen by 3D ASL. Conclusions: 3D ASL renal perfusion imaging provides isotropic-resolution images, with comparable quantitative perfusion values and image SNR in similar imaging time to single-slice 2D ASL.

KW - Arterial spin labeling

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KW - Kidney disease

KW - MRI

KW - Perfusion

KW - Renal cell carcinoma

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