Volumetric contrast-enhanced ultrasound for characterizing tumor vascularity: Preliminary studies in an animal model

Kenneth Hoyt, Anna G. Sorace

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper describes a volumetric strategy for characterization of tumor blood flow using microbubble (MB) contrast agents and ultrasound (US) imaging. Volumetric contrast-enhanced US (VCEUS) imaging was implemented on a SONIX RP US system (Ultrasonix Medical Corp) equipped with a broadband 4DL14-5/38 probe. Acquisition of VCEUS data was achieved at a volume rate of 1 Hz using a MB sensitive harmonic imaging mode. Following MB infusion, custom Matlab programs were used to compute MB time-intensity curve-specific parameters: blood volume (I PK), transit time (T 1/2PK), flow rate (S PK), and tumor perfusion (AUC). Using a xenograft model of human breast cancer, it is shown that millimeter-sized deviations in transducer positioning can have profound implications on US-based blood flow estimators with errors ranging from 6.4 to 40.3% and dependent on both degree of misalignment and particular blood flow estimator. These errors indicate that VCEUS imaging should be considered in tumor analyses because they incorporate the entire mass and not just a representative planar cross-section.

Original languageEnglish (US)
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages1292-1295
Number of pages4
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period10/18/1110/21/11

Keywords

  • contrast agent
  • microbubble
  • tumor perfusion
  • ultrasound
  • volumetric imaging

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Volumetric contrast-enhanced ultrasound for characterizing tumor vascularity: Preliminary studies in an animal model'. Together they form a unique fingerprint.

  • Cite this

    Hoyt, K., & Sorace, A. G. (2011). Volumetric contrast-enhanced ultrasound for characterizing tumor vascularity: Preliminary studies in an animal model. In 2011 IEEE International Ultrasonics Symposium, IUS 2011 (pp. 1292-1295). [6293598] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2011.0319