Vulvar nevi, melanosis, and melanoma: An epidemiologic, clinical, and histopathologic review

Era Caterina Murzaku, Lauren A. Penn, Christopher S. Hale, Miriam Keltz Pomeranz, David Polsky

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Pigmented vulvar lesions are present in approximately 1 in 10 women and include melanocytic and nonmelanocytic proliferations. Vulvar nevi, melanosis, and melanoma are particularly challenging because of the similarity of their clinical and/or histopathological presentation. As a result, they are often difficult to diagnose, may result in patient and physician anxiety, and can lead to unneeded, potentially disfiguring surgical procedures. Because it is often detected late, vulvar melanoma carries a poor prognosis with associated significant morbidity and mortality, underscoring the importance of prompt recognition and treatment. In this review, we analyze the distinct epidemiologic, clinical, and histopathologic characteristics of vulvar nevi, melanosis, and melanoma, discuss treatment options, and propose a practical, systematic approach to facilitate formulation of a differential diagnosis and initiation of appropriate management.

Original languageEnglish (US)
Pages (from-to)1241-1249
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume71
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Fingerprint

Nevi and Melanomas
Melanosis
Melanoma
Differential Diagnosis
Anxiety
Morbidity
Physicians
Mortality
Therapeutics

Keywords

  • dermoscopy
  • melanocytic nevi
  • melanoma
  • melanosis
  • pigmented lesions
  • reflectance confocal microscopy
  • vulvar region

ASJC Scopus subject areas

  • Dermatology

Cite this

Vulvar nevi, melanosis, and melanoma : An epidemiologic, clinical, and histopathologic review. / Murzaku, Era Caterina; Penn, Lauren A.; Hale, Christopher S.; Pomeranz, Miriam Keltz; Polsky, David.

In: Journal of the American Academy of Dermatology, Vol. 71, No. 6, 01.12.2014, p. 1241-1249.

Research output: Contribution to journalReview article

Murzaku, Era Caterina ; Penn, Lauren A. ; Hale, Christopher S. ; Pomeranz, Miriam Keltz ; Polsky, David. / Vulvar nevi, melanosis, and melanoma : An epidemiologic, clinical, and histopathologic review. In: Journal of the American Academy of Dermatology. 2014 ; Vol. 71, No. 6. pp. 1241-1249.
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