Waldenstrom macroglobulinemia with an IgM-κ antiepidermal basement membrane zone antibody

M. W. Cobb, N. Domloge-Hultsch, J. N. Frame, K. B. Yancey

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22 Citations (Scopus)

Abstract

Background.-Waldenstrom macroglobulinemia, a lymphoplasmacytoid cell malignant neoplasm associated with a monoclonal IgM paraprotein, has been associated with a number of cutaneous manifestations. On rare occasions, IgM deposits have been demonstrated in the epidermal basement zone of patients with WM. Observations.-We report the case of a patient with Waldenstrom macroglobulinemia and IgM-κ paraprotein who had development of an eruption of pruritic papules and demonstrated the following unusual immunopathologic findings: (1) deposits of IgM-κ in the epidermal basement membrane zone of lesional and nonlesional skin; (2) a circulating IgM-κ antiepidermal basement membrane zone antibody; and (3) binding of this circulating IgM-κ antiepidermal basement membrane zone antibody to both sides of 1 mol/L sodium chloride split skin. The cutaneous eruption cleared completely with oral psoralen with long-wave UV radiation in the A range (PUVA) therapy. Conclusions.-We present a patient with Waldenstrom macroglobulinemia who had a distinctive papular eruption and immunopathologic findings suggesting that his paraprotein has specificity for the epidermal basement membrane zone.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalArchives of Dermatology
Volume128
Issue number3
DOIs
StatePublished - 1992

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Waldenstrom Macroglobulinemia
Basement Membrane
Immunoglobulin M
Paraproteins
Antibodies
Skin
PUVA Therapy
Ficusin
Skin Manifestations
Sodium Chloride
Radiation
Neoplasms

ASJC Scopus subject areas

  • Dermatology

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Waldenstrom macroglobulinemia with an IgM-κ antiepidermal basement membrane zone antibody. / Cobb, M. W.; Domloge-Hultsch, N.; Frame, J. N.; Yancey, K. B.

In: Archives of Dermatology, Vol. 128, No. 3, 1992, p. 372-376.

Research output: Contribution to journalArticle

Cobb, M. W. ; Domloge-Hultsch, N. ; Frame, J. N. ; Yancey, K. B. / Waldenstrom macroglobulinemia with an IgM-κ antiepidermal basement membrane zone antibody. In: Archives of Dermatology. 1992 ; Vol. 128, No. 3. pp. 372-376.
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