Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy

Fenghua Tian, Takashi Tarumi, Hanli Liu, Rong Zhang, Lina Chalak

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed cerebral autoregulation in nine newborns with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). These neonates received hypothermic therapy during the first 72 h of life while mean arterial pressure (MAP) and cerebral tissue oxygenation saturation (SctO2) were continuously recorded. Wavelet coherence analysis, which is a time-frequency domain approach, was used to characterize the dynamic relationship between spontaneous oscillations in MAP and SctO2. Wavelet-based metrics of phase, coherence and gain were derived for quantitative evaluation of cerebral autoregulation. We found cerebral autoregulation in neonates with HIE was time-scale-dependent in nature. Specifically, the spontaneous changes in MAP and SctO2 had in-phase coherence at time scales of less than 80 min (<0.0002 Hz in frequency), whereas they showed anti-phase coherence at time scales of around 2.5 h (~ 0.0001 Hz in frequency). Both the in-phase and anti-phase coherence appeared to be related to worse clinical outcomes. These findings suggest the potential clinical use of wavelet coherence analysis to assess dynamic cerebral autoregulation in neonatal HIE during hypothermia.

Original languageEnglish (US)
Pages (from-to)124-132
Number of pages9
JournalNeuroImage: Clinical
Volume11
DOIs
StatePublished - 2016

Fingerprint

Brain Hypoxia-Ischemia
Wavelet Analysis
Homeostasis
Arterial Pressure
Brain
Hypothermia
Perfusion
Blood Pressure

Keywords

  • Cerebral autoregulation
  • Hypothermia
  • Hypoxic-ischemic encephalopathy (HIE)
  • Near infrared spectroscopy (NIRS)
  • Wavelet coherence

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy. / Tian, Fenghua; Tarumi, Takashi; Liu, Hanli; Zhang, Rong; Chalak, Lina.

In: NeuroImage: Clinical, Vol. 11, 2016, p. 124-132.

Research output: Contribution to journalArticle

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