Web-based communications and management of a multi-center clinical trial: The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project

Stephen R. Wisniewski, Heather Eng, Leslie Meloro, Robert Gatt, Louise Ritz, Diane Stegman, Madhukar Trivedi, Melanie M. Biggs, Edward Friedman, Kathy Shores-Wilson, Diane Warden, Douglas Bartolowits, Jeffrey P. Martin, A. John Rush

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34 Scopus citations

Abstract

While efficient methods of communication are known to be essential in conducting large multicenter clinical trials, very little information is provided on actual methods that can be implemented to improve communication. An integrated technology-based communication system was developed for the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project, which prospectively defines treatments that are most effective for participants with a diagnosis of a nonpsychotic major depressive disorder (MDD) who report an unsatisfactory clinical outcome to an initial and, if necessary, subsequent treatment(s). This web-based communication system is comprised of a multi-faceted study Web site, including a help desk, document sharing, a project directory and reports. In addition, automated reporting via e-mail and an online data correction mechanism are also available. The STARD communication system improves communication between study personnel and improves the quality of the study's data through the integration of system elements, the integration of those elements with traditional forms of communication, by filling the gaps not addressed by those traditional methods and by reducing the staff workload burden.

Original languageEnglish (US)
Pages (from-to)387-398
Number of pages12
JournalClinical Trials
Volume1
Issue number4
DOIs
StatePublished - Aug 2004

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Wisniewski, S. R., Eng, H., Meloro, L., Gatt, R., Ritz, L., Stegman, D., Trivedi, M., Biggs, M. M., Friedman, E., Shores-Wilson, K., Warden, D., Bartolowits, D., Martin, J. P., & Rush, A. J. (2004). Web-based communications and management of a multi-center clinical trial: The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project. Clinical Trials, 1(4), 387-398. https://doi.org/10.1191/1740774504cn035oa