What causes the insulin resistance underlying obesity?

Olga T. Hardy, Michael P. Czech, Silvia Corvera

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The association between obesity and insulin resistance is an area of much interest and enormous public health impact, with hundreds of articles being published in the last year focused on the possible mechanisms that underlie this association. The purpose to this review is to highlight some of the key recent literature with emphasis on emerging concepts. RECENT FINDINGS: The specific link between visceral adipose tissue accumulation and insulin resistance continues to be discerned. Visceral adiposity is correlated with accumulation of excess lipid in liver, and results in cell autonomous impairment in insulin signaling. Visceral adipose tissue is also prone to inflammation and inflammatory cytokine production, which also contribute to impairment in insulin signaling. The expansion of visceral adipose tissue and excess lipid accumulation in liver and muscle may result from limited expandability of subcutaneous adipose tissue, due to the properties of its extracellular matrix and capacity for capillary growth. SUMMARY: Recent studies underscore the need to better understand the mechanisms linking visceral adiposity with liver fat accumulation, the mechanisms by which ectopic fat accumulation cause insulin resistance, and the mechanisms by which the size of adipose tissue depots is determined.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume19
Issue number2
DOIs
StatePublished - Apr 2012

Fingerprint

Intra-Abdominal Fat
Insulin Resistance
Obesity
Adiposity
Liver
Fats
Insulin
Lipids
Subcutaneous Fat
Extracellular Matrix
Adipose Tissue
Public Health
Cytokines
Inflammation
Muscles
Growth

Keywords

  • adipose tissue expandability
  • inflammation
  • insulin resistance
  • lipotoxicity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

What causes the insulin resistance underlying obesity? / Hardy, Olga T.; Czech, Michael P.; Corvera, Silvia.

In: Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 19, No. 2, 04.2012, p. 81-87.

Research output: Contribution to journalArticle

Hardy, Olga T. ; Czech, Michael P. ; Corvera, Silvia. / What causes the insulin resistance underlying obesity?. In: Current Opinion in Endocrinology, Diabetes and Obesity. 2012 ; Vol. 19, No. 2. pp. 81-87.
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