TY - JOUR
T1 - What Pathogens Have Taught Us about Posttranslational Modifications
AU - Salomon, Dor
AU - Orth, Kim
N1 - Funding Information:
We thank members of the Orth lab for editing and helpful discussions. K.O. and D.S. are supported by grants from NIH-Allergy and Infectious Disease (R21-AI096133 and R01-AI087808) and the Welch Foundation (I-1561). K.O. is a Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease and a W.W. Caruth Jr. Biomedical Scholar and has an Earl A. Forsythe Chair in Biomedical Science.
PY - 2013/9/11
Y1 - 2013/9/11
N2 - Pathogens use various mechanisms to manipulate host processes to promote infection. Decades of research on pathogens have revealed not only the molecular mechanisms that these microbes use to replicate and survive within host cells, but also seminal information on how host signaling machinery regulates cellular processes. Among these discoveries are mechanisms involving posttranslational modifications that alter the activity, localization, or interactions of the modified protein. Herein, we examine how pathogens have contributed to our basic understanding of three posttranslational modifications: phosphorylation, NMPylation, and ubiquitylation. Over the years, technologies, techniques and research tools have developed side by side with the study of pathogens, facilitating the discovery of protein modifications and furthering our understanding of how they contribute to both infection and cellular functions.
AB - Pathogens use various mechanisms to manipulate host processes to promote infection. Decades of research on pathogens have revealed not only the molecular mechanisms that these microbes use to replicate and survive within host cells, but also seminal information on how host signaling machinery regulates cellular processes. Among these discoveries are mechanisms involving posttranslational modifications that alter the activity, localization, or interactions of the modified protein. Herein, we examine how pathogens have contributed to our basic understanding of three posttranslational modifications: phosphorylation, NMPylation, and ubiquitylation. Over the years, technologies, techniques and research tools have developed side by side with the study of pathogens, facilitating the discovery of protein modifications and furthering our understanding of how they contribute to both infection and cellular functions.
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U2 - 10.1016/j.chom.2013.07.008
DO - 10.1016/j.chom.2013.07.008
M3 - Review article
C2 - 24034613
AN - SCOPUS:84883867139
SN - 1931-3128
VL - 14
SP - 269
EP - 279
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 3
ER -