When the message goes awry: Disease-producing mutations that influence mRNA content and performance

Joshua T. Mendell, Harry C. Dietz

Research output: Contribution to journalReview article

221 Scopus citations

Abstract

Mutations that cause disease commonly occur in the coding sequence and directly influence protein structure and function. However, many diseases result from mutations that influence various aspects of mRNA metabolism, including processing, export, stability, and translational control.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalCell
Volume107
Issue number4
DOIs
StatePublished - Nov 16 2001

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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