When the message goes awry: Disease-producing mutations that influence mRNA content and performance

Joshua T. Mendell, Harry C. Dietz

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Mutations that cause disease commonly occur in the coding sequence and directly influence protein structure and function. However, many diseases result from mutations that influence various aspects of mRNA metabolism, including processing, export, stability, and translational control.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalCell
Volume107
Issue number4
DOIs
StatePublished - Nov 16 2001

Fingerprint

Messenger RNA
Mutation
Metabolism
Processing
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

When the message goes awry : Disease-producing mutations that influence mRNA content and performance. / Mendell, Joshua T.; Dietz, Harry C.

In: Cell, Vol. 107, No. 4, 16.11.2001, p. 411-414.

Research output: Contribution to journalArticle

@article{9189807573fa4716be7931c4ebd84657,
title = "When the message goes awry: Disease-producing mutations that influence mRNA content and performance",
abstract = "Mutations that cause disease commonly occur in the coding sequence and directly influence protein structure and function. However, many diseases result from mutations that influence various aspects of mRNA metabolism, including processing, export, stability, and translational control.",
author = "Mendell, {Joshua T.} and Dietz, {Harry C.}",
year = "2001",
month = "11",
day = "16",
doi = "10.1016/S0092-8674(01)00583-9",
language = "English (US)",
volume = "107",
pages = "411--414",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - When the message goes awry

T2 - Disease-producing mutations that influence mRNA content and performance

AU - Mendell, Joshua T.

AU - Dietz, Harry C.

PY - 2001/11/16

Y1 - 2001/11/16

N2 - Mutations that cause disease commonly occur in the coding sequence and directly influence protein structure and function. However, many diseases result from mutations that influence various aspects of mRNA metabolism, including processing, export, stability, and translational control.

AB - Mutations that cause disease commonly occur in the coding sequence and directly influence protein structure and function. However, many diseases result from mutations that influence various aspects of mRNA metabolism, including processing, export, stability, and translational control.

UR - http://www.scopus.com/inward/record.url?scp=0035900647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035900647&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(01)00583-9

DO - 10.1016/S0092-8674(01)00583-9

M3 - Article

C2 - 11719181

AN - SCOPUS:0035900647

VL - 107

SP - 411

EP - 414

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -