Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging

Nathan A. DeCarolis, Keith A. Wharton, Amelia J. Eisch

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by β-catentin. Emerging evidence suggests that canonical Wnt signaling influences cellular aging, indicating that increases in Wnt signaling delay age-related deficits.(1) However, recent Science papers suggest that Wnt signaling accelerates the onset of aging.(2,3) In an attempt to resolve this paradox and clarify how Wnt signaling affects aging, we provide a selective review of research relevant to Wnt signaling and aging.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalBioEssays
Volume30
Issue number2
DOIs
StatePublished - Feb 2008

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Cell Aging
stem cells
Stem Cells
Aging of materials
Maintenance
Research
Cell signaling
Stem cells

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. / DeCarolis, Nathan A.; Wharton, Keith A.; Eisch, Amelia J.

In: BioEssays, Vol. 30, No. 2, 02.2008, p. 102-106.

Research output: Contribution to journalArticle

DeCarolis, Nathan A. ; Wharton, Keith A. ; Eisch, Amelia J. / Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. In: BioEssays. 2008 ; Vol. 30, No. 2. pp. 102-106.
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