White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event

Lei Li, Du Lei, Lingjiang Li, Xiaoqi Huang, Xueling Suo, Fenglai Xiao, Weihong Kuang, Jin Li, Feng Bi, Su Lui, Graham J. Kemp, John A. Sweeney, Qiyong Gong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Studies of posttraumatic stress disorder (PTSD) are complicated by wide variability in the intensity and duration of prior stressors in patient participants, secondary effects of chronic psychiatric illness, and a variable history of treatment with psychiatric medications. In magnetic resonance imaging (MRI) studies, patient samples have often been small, and they were not often compared to similarly stressed patients without PTSD in order to control for general stress effects. Findings from these studies have been inconsistent. The present study investigated whole-brain microstructural alterations of white matter in a large drug-naive population who survived a specific, severe traumatic event (a major 8.0-magnitude earthquake). Using diffusion tensor imaging (DTI), we explored group differences between 88 PTSD patients and 91 matched traumatized non-PTSD controls in fractional anisotropy (FA), as well as its component elements axial diffusivity (AD) and radial diffusivity (RD), and examined these findings in relation to findings from deterministic DTI tractography. Relations between white matter alterations and psychiatric symptom severity were examined. PTSD patients, relative to similarly stressed controls, showed an FA increase as well as AD and RD changes in the white matter beneath left dorsolateral prefrontal cortex and forceps major. The observation of increased FA in the PTSD group suggests that the pathophysiology of PTSD after a specific acute traumatic event is distinct from what has been reported in patients with several years duration of illness. Alterations in dorsolateral prefrontal cortex may be an important aspect of illness pathophysiology, possibly via the region's established role in fear extinction circuitry. Use-dependent myelination or other secondary compensatory changes in response to heightened demands for threat appraisal and emotion regulation may be involved.

Original languageEnglish (US)
JournalEBioMedicine
DOIs
StateAccepted/In press - Oct 3 2015

Fingerprint

Post-Traumatic Stress Disorders
Diffusion tensor imaging
Anisotropy
Psychiatry
Diffusion Tensor Imaging
Prefrontal Cortex
Magnetic resonance
Brain
Earthquakes
Imaging techniques
Surgical Instruments
Fear
White Matter
Emotions
Chronic Disease
Magnetic Resonance Imaging
Observation
Pharmaceutical Preparations
Population

Keywords

  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • Mental disorders
  • Neuroimaging
  • Posttraumatic stress disorder
  • Psychoradiology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event. / Li, Lei; Lei, Du; Li, Lingjiang; Huang, Xiaoqi; Suo, Xueling; Xiao, Fenglai; Kuang, Weihong; Li, Jin; Bi, Feng; Lui, Su; Kemp, Graham J.; Sweeney, John A.; Gong, Qiyong.

In: EBioMedicine, 03.10.2015.

Research output: Contribution to journalArticle

Li, L, Lei, D, Li, L, Huang, X, Suo, X, Xiao, F, Kuang, W, Li, J, Bi, F, Lui, S, Kemp, GJ, Sweeney, JA & Gong, Q 2015, 'White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event', EBioMedicine. https://doi.org/10.1016/j.ebiom.2016.01.012
Li, Lei ; Lei, Du ; Li, Lingjiang ; Huang, Xiaoqi ; Suo, Xueling ; Xiao, Fenglai ; Kuang, Weihong ; Li, Jin ; Bi, Feng ; Lui, Su ; Kemp, Graham J. ; Sweeney, John A. ; Gong, Qiyong. / White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event. In: EBioMedicine. 2015.
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