TY - JOUR
T1 - White matter disruptions in adolescents exposed to childhood maltreatment and vulnerability to psychopathology
AU - Huang, Hao
AU - Gundapuneedi, Tejasvi
AU - Rao, Uma
N1 - Funding Information:
This work was supported, in part, by grants RO1 DA014037 (UR), RO1 DA015131 (UR), RO1 DA017804 (UR), RO1 DA017805 (UR), RO1 MH062464 (UR), RO1 MH068391 (UR), G12 RR003032 (UR), UL1 RR024975 (UR), U54 RR026140/U54 MD007593 (UR), RO1 MH092535 (HH), and R21 EB009545 (HH) from the National Institutes of Health, the Endowed Chair in Brain and Behavior Research at Meharry Medical College, and the Sarah M and Charles E Seay Endowed Chair in Child Psychiatry at UT South-western Medical Center. We also thank Dr Min Chen from the Department of Clinical Science at UT Southwestern Medical Center for his statistical assistance.
PY - 2012/11
Y1 - 2012/11
N2 - Childhood maltreatment has been known to produce long-lasting impairments in behavioral, cognitive and social functioning, but their underlying mechanisms are not well-understood. A better understanding of their underlying mechanisms will aid in developing effective preventive interventions. Nineteen adolescent volunteers with no personal history of a psychiatric illness, but who were exposed to maltreatment during childhood, and 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) underwent diffusion tensor imaging (DTI) studies. The participants were then followed longitudinally at 6-month intervals for up to 5 years to determine the onset of mood and substance use disorders. The associations among fractional anisotropy (FA) values obtained from the DTI scans at baseline and psychopathology at follow-up were examined. At baseline, adolescents exposed to childhood maltreatment had significantly lower FA values in the left and right superior longitudinal fasciculi, right cingulum bundle projecting to the hippocampus, left inferior fronto-occipital fasciculus, and splenium of the corpus callosum compared with controls. Adolescents who developed major depressive disorder at follow-up had significantly lower FA values in the superior longitudinal fasciculi and the right cingulum-hippocampal projection compared with their counterparts who did not develop the illness. Adolescents who developed substance use disorder during follow-up had significantly lower FA values in the right cingulum-hippocampal projection than their counterparts without the disorder. These preliminary results suggest that white matter disruptions observed in adolescents exposed to childhood maltreatment may be associated with increased vulnerability to psychopathology, specifically depressive and substance use disorders.
AB - Childhood maltreatment has been known to produce long-lasting impairments in behavioral, cognitive and social functioning, but their underlying mechanisms are not well-understood. A better understanding of their underlying mechanisms will aid in developing effective preventive interventions. Nineteen adolescent volunteers with no personal history of a psychiatric illness, but who were exposed to maltreatment during childhood, and 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) underwent diffusion tensor imaging (DTI) studies. The participants were then followed longitudinally at 6-month intervals for up to 5 years to determine the onset of mood and substance use disorders. The associations among fractional anisotropy (FA) values obtained from the DTI scans at baseline and psychopathology at follow-up were examined. At baseline, adolescents exposed to childhood maltreatment had significantly lower FA values in the left and right superior longitudinal fasciculi, right cingulum bundle projecting to the hippocampus, left inferior fronto-occipital fasciculus, and splenium of the corpus callosum compared with controls. Adolescents who developed major depressive disorder at follow-up had significantly lower FA values in the superior longitudinal fasciculi and the right cingulum-hippocampal projection compared with their counterparts who did not develop the illness. Adolescents who developed substance use disorder during follow-up had significantly lower FA values in the right cingulum-hippocampal projection than their counterparts without the disorder. These preliminary results suggest that white matter disruptions observed in adolescents exposed to childhood maltreatment may be associated with increased vulnerability to psychopathology, specifically depressive and substance use disorders.
KW - DTI
KW - adolescent
KW - maltreatment
KW - psychopathology
KW - superior longitudinal fasciculus
KW - white matter
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U2 - 10.1038/npp.2012.133
DO - 10.1038/npp.2012.133
M3 - Article
C2 - 22850736
AN - SCOPUS:84867574283
SN - 0893-133X
VL - 37
SP - 2693
EP - 2701
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 12
ER -