Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans

Vanessa L. Cropley, Masahiro Fujita, John L. Musachio, Jinsoo Hong, Subroto Ghose, Janet Sangare, Pradeep J. Nathan, Victor W. Pike, Robert B. Innis

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The present study estimated radiation-absorbed doses of the dopamine D 1 receptor radioligand [11C]((1)-8-chloro-5-(7- benzofuranyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) (NNC 112) in humans, based on dynamic whole-body PET in healthy subjects. Methods: Whole-body PET was performed on 7 subjects after injection of 710 ± 85 MBq of 11C-NNC 112. Fourteen frames were acquired for a total of 120 min in 7 segments of the body. Regions of interest were drawn on compressed planar images of source organs that could be identified. Radiation dose estimates were calculated from organ residence times using the OLINDA 1.0 program. Results: The organs with the highest radiation-absorbed doses were the gall-bladder, liver, lungs, kidneys, and urinary bladder wall. Biexponential fitting of mean bladder activity demonstrated that 15% of activity was excreted via the urine. With a 2.4-h voiding interval, the effective dose was 5.7 μSv/MBq (21.1 mrem/mCi). Conclusion: 11C-NNC 112 displays a favorable radiation dose profile in humans and would allow multiple PET examinations per year to be performed on the same subject.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalJournal of Nuclear Medicine
Volume47
Issue number1
StatePublished - Jan 1 2006

Keywords

  • C-NNC 112
  • D receptor
  • Dosimetry
  • Effective dose
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Cropley, V. L., Fujita, M., Musachio, J. L., Hong, J., Ghose, S., Sangare, J., Nathan, P. J., Pike, V. W., & Innis, R. B. (2006). Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans. Journal of Nuclear Medicine, 47(1), 100-104.