Whole body heat stress attenuates baroreflex control of muscle sympathetic nerve activity during postexercise muscle ischemia

Jian Cui, Manabu Shibasaki, Scott L. Davis, David A. Low, David M. Keller, Craig G. Crandall

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Both whole body heat stress and stimulation of muscle metabolic receptors activate muscle sympathetic nerve activity (MSNA) through nonbaroreflex pathways. In addition to stimulating muscle metaboreceptors, exercise has the potential to increase internal temperature. Although we and others report that passive whole body heating does not alter the gain of the arterial baroreflex, it is unknown whether increased body temperature, often accompanying exercise, affects baroreflex function when muscle metaboreceptors are stimulated. This project tested the hypothesis that whole body heating alters the gain of baroreflex control of muscle sympathetic nerve activity (MSNA) and heart rate during muscle metaboreceptor stimulation engaged via postexercise muscle ischemia (PEMI). MSNA, blood pressure (BP, Finometer), and heart rate were recorded from 11 healthy volunteers. The volunteers performed isometric handgrip exercise until fatigue, followed by 2.5 min of PEMI. During PEMI, BP was acutely reduced and then raised pharmacologically using the modified Oxford technique. This protocol was repeated two to three times when volunteers were normothermic, and again during heat stress (increase core temperature ∼ 0.7°C) conditions. The slope of the relationship between MSNA and BP during PEMI was less negative (i.e., decreased baroreflex gain) during whole body heating when compared with the normothermic condition (-4.34 ± 0.40 to -3.57 ± 0.31 units·beat-1middot;mmHg-1, respectively; P = 0.015). The gain of baroreflex control of heart rate during PEMI was also decreased during whole body heating (P < 0.001). These findings indicate that whole body heat stress reduces baroreflex control of MSNA and heart rate during muscle metaboreceptor stimulation.

Original languageEnglish (US)
Pages (from-to)1125-1131
Number of pages7
JournalJournal of Applied Physiology
Volume106
Issue number4
DOIs
StatePublished - Apr 2009

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Baroreflex
Ischemia
Hot Temperature
Muscles
Heating
Heart Rate
Exercise
Volunteers
Temperature
Body Temperature
Fatigue

Keywords

  • Muscle metaboreceptors
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Whole body heat stress attenuates baroreflex control of muscle sympathetic nerve activity during postexercise muscle ischemia. / Cui, Jian; Shibasaki, Manabu; Davis, Scott L.; Low, David A.; Keller, David M.; Crandall, Craig G.

In: Journal of Applied Physiology, Vol. 106, No. 4, 04.2009, p. 1125-1131.

Research output: Contribution to journalArticle

Cui, Jian ; Shibasaki, Manabu ; Davis, Scott L. ; Low, David A. ; Keller, David M. ; Crandall, Craig G. / Whole body heat stress attenuates baroreflex control of muscle sympathetic nerve activity during postexercise muscle ischemia. In: Journal of Applied Physiology. 2009 ; Vol. 106, No. 4. pp. 1125-1131.
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