Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Mitsuaki Kashiwagi, Mika Kanuka, Chika Tatsuzawa, Hitomi Suzuki, Miho Morita, Kaeko Tanaka, Taizo Kawano, Jay W. Shin, Harukazu Suzuki, Shigeyoshi Itohara, Masashi Yanagisawa, Yu Hayashi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Kashiwagi et al. identify a novel NREM sleep-promoting neural circuit distributed in the midbrain, pons, and medulla. All the neurons of this circuit are positive for the neuropeptide neurotensin, and neurotensin itself is involved in sleep regulation.

Original languageEnglish (US)
Pages (from-to)1002-1010.e4
JournalCurrent Biology
Volume30
Issue number6
DOIs
StatePublished - Mar 23 2020

Keywords

  • DREADD
  • Nts
  • SubLDT
  • brainstem
  • chemogenetics
  • mouse
  • neurotensin
  • sleep

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., Yanagisawa, M., & Hayashi, Y. (2020). Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice. Current Biology, 30(6), 1002-1010.e4. https://doi.org/10.1016/j.cub.2020.01.047