Willingness to participate in cardiac trials.

Eric D. Peterson, Barbara L. Lytle, Mimi S. Biswas, Laura Coombs

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The elderly, women, and minorities are all less likely to be enrolled in randomized clinical trials (RCTs). Whether differential patient interest in RCTs contributes to these disparities is unclear. The authors surveyed 660 patients willingness to consider two potential cardiac RCTs of medical therapy vs. percutaneous coronary angioplasty or coronary artery bypass surgery, respectively. The cohorts mean age was 67 years (43% aged >or=70 years; 35% women; and 28% nonwhite). Compared with younger patients, those aged >or=70 years were equal or more likely to consider both the percutaneous coronary angioplasty (46% vs. 41%) and coronary artery bypass surgery RCTs (35% vs. 31%). Race also had no significant impact on trial enrollment, yet women were significantly less likely than men to participate in either RCT. In conclusion, patient willingness to consider RCT participation does not explain underenrollment of elderly and minority patients. Women, however, were more reluctant to consider RCTs, an area requiring further study.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalThe American journal of geriatric cardiology
Issue number1
StatePublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Gerontology
  • Health Policy
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine


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