Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo

Gogineni Ranganayakulu, Robert A. Schulz, Eric N. Olson

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Abstract

The segregation of founder cells from the somatic mesoderm is a prerequisite for the formation of body wall muscles in the Drosophila embryo. The myogenic basic helix-loop-helix protein, Nautilus (Nau), is expressed in a subset of these founder cells in medial and lateral positions in the somatic mesoderm. Mutations in the wingless (wg) gene, which encodes a secreted growth factor, lead to the complete loss of Nau-expressing medial muscle precursor cell clusters, but not lateral clusters. Using the GAL4/UAS system, we demonstrate that the wg-derived signal can originate from either ectoderm or mesoderm to influence nau expression. By using a temperature-sensitive wg allele, we also show that wg function is required during and after gastrulation for the formation of Nau-expressing medial muscle precursor cell clusters. Our results, combined with recent studies from chick, suggest a conserved role for Wg signaling pathways during muscle development.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalDevelopmental Biology
Volume176
Issue number1
DOIs
Publication statusPublished - May 25 1996

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ASJC Scopus subject areas

  • Developmental Biology

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