Wireless, implantable catheter-type oximeter designed for cardiac oxygen saturation

Wei Lu, Wubin Bai, Hao Zhang, Chenkai Xu, Antonio M. Chiarelli, Abraham Vázquez-Guardado, Zhaoqian Xie, Haixu Shen, Khizar Nandoliya, Hangbo Zhao, Kun Hyuck Lee, Yixin Wu, Daniel Franklin, Raudel Avila, Shuai Xu, Alina Rwei, Mengdi Han, Kyeongha Kwon, Yujun Deng, Xinge YuEdward B. Thorp, Xue Feng, Yonggang Huang, Joseph Forbess, Zhi Dong Ge, John A. Rogers

Research output: Contribution to journalArticlepeer-review

Abstract

Accurate, real-time monitoring of intravascular oxygen levels is important in tracking the cardiopulmonary health of patients after cardiothoracic surgery. Existing technologies use intravascular placement of glass fiber-optic catheters that pose risks of blood vessel damage, thrombosis, and infection. In addition, physical tethers to power supply systems and data acquisition hardware limit freedom of movement and add clutter to the intensive care unit. This report introduces a wireless, miniaturized, implantable optoelectronic catheter system incorporating optical components on the probe, encapsulated by soft biocompatible materials, as alternative technology that avoids these disadvantages. The absence of physical tethers and the flexible, biocompatible construction of the probe represent key defining features, resulting in a high-performance, patient-friendly implantable oximeter that can monitor localized tissue oxygenation, heart rate, and respiratory activity with wireless, real-time, continuous operation. In vitro and in vivo testing shows that this platform offers measurement accuracy and precision equivalent to those of existing clinical standards.

Original languageEnglish (US)
Article numbereabe0579
JournalScience Advances
Volume7
Issue number7
DOIs
StatePublished - Feb 10 2021
Externally publishedYes

ASJC Scopus subject areas

  • General

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