TY - JOUR
T1 - Wireless, implantable catheter-type oximeter designed for cardiac oxygen saturation
AU - Lu, Wei
AU - Bai, Wubin
AU - Zhang, Hao
AU - Xu, Chenkai
AU - Chiarelli, Antonio M.
AU - Vázquez-Guardado, Abraham
AU - Xie, Zhaoqian
AU - Shen, Haixu
AU - Nandoliya, Khizar
AU - Zhao, Hangbo
AU - Lee, Kun Hyuck
AU - Wu, Yixin
AU - Franklin, Daniel
AU - Avila, Raudel
AU - Xu, Shuai
AU - Rwei, Alina
AU - Han, Mengdi
AU - Kwon, Kyeongha
AU - Deng, Yujun
AU - Yu, Xinge
AU - Thorp, Edward B.
AU - Feng, Xue
AU - Huang, Yonggang
AU - Forbess, Joseph
AU - Ge, Zhi Dong
AU - Rogers, John A.
N1 - Publisher Copyright:
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2021/2/10
Y1 - 2021/2/10
N2 - Accurate, real-time monitoring of intravascular oxygen levels is important in tracking the cardiopulmonary health of patients after cardiothoracic surgery. Existing technologies use intravascular placement of glass fiber-optic catheters that pose risks of blood vessel damage, thrombosis, and infection. In addition, physical tethers to power supply systems and data acquisition hardware limit freedom of movement and add clutter to the intensive care unit. This report introduces a wireless, miniaturized, implantable optoelectronic catheter system incorporating optical components on the probe, encapsulated by soft biocompatible materials, as alternative technology that avoids these disadvantages. The absence of physical tethers and the flexible, biocompatible construction of the probe represent key defining features, resulting in a high-performance, patient-friendly implantable oximeter that can monitor localized tissue oxygenation, heart rate, and respiratory activity with wireless, real-time, continuous operation. In vitro and in vivo testing shows that this platform offers measurement accuracy and precision equivalent to those of existing clinical standards.
AB - Accurate, real-time monitoring of intravascular oxygen levels is important in tracking the cardiopulmonary health of patients after cardiothoracic surgery. Existing technologies use intravascular placement of glass fiber-optic catheters that pose risks of blood vessel damage, thrombosis, and infection. In addition, physical tethers to power supply systems and data acquisition hardware limit freedom of movement and add clutter to the intensive care unit. This report introduces a wireless, miniaturized, implantable optoelectronic catheter system incorporating optical components on the probe, encapsulated by soft biocompatible materials, as alternative technology that avoids these disadvantages. The absence of physical tethers and the flexible, biocompatible construction of the probe represent key defining features, resulting in a high-performance, patient-friendly implantable oximeter that can monitor localized tissue oxygenation, heart rate, and respiratory activity with wireless, real-time, continuous operation. In vitro and in vivo testing shows that this platform offers measurement accuracy and precision equivalent to those of existing clinical standards.
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U2 - 10.1126/sciadv.abe0579
DO - 10.1126/sciadv.abe0579
M3 - Article
C2 - 33568482
AN - SCOPUS:85100953499
SN - 2375-2548
VL - 7
JO - Science Advances
JF - Science Advances
IS - 7
M1 - eabe0579
ER -