Within-individual stability of obesity-related biomarkers among women

Robert C. Kaplan, Gloria Y F Ho, XiaoNan Xue, Swapnil Rajpathak, Mary Cushman, Thomas E. Rohan, Howard D. Strickler, Philipp E. Scherer, Kathryn Anastos

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested. Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor α, interleukin 6, and insulin among healthy young women. Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other race/ethnicity) with mean age of 32.3 years, mean body mass index of 31.2 kg/m2, and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor α (0.39), and interleukin 6 (0.47). Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2007

Fingerprint

Obesity
Biomarkers
Resistin
Hepatocyte Growth Factor
Adiponectin
Leptin
Hispanic Americans
Interleukin-6
Tumor Necrosis Factor-alpha
Smoking
Insulin
Cytokines
Adipokines
Feasibility Studies
Longitudinal Studies
Neoplasms
Body Mass Index
Outcome Assessment (Health Care)
Prospective Studies
Health

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Kaplan, R. C., Ho, G. Y. F., Xue, X., Rajpathak, S., Cushman, M., Rohan, T. E., ... Anastos, K. (2007). Within-individual stability of obesity-related biomarkers among women. Cancer Epidemiology Biomarkers and Prevention, 16(6), 1291-1293. https://doi.org/10.1158/1055-9965.EPI-06-1089

Within-individual stability of obesity-related biomarkers among women. / Kaplan, Robert C.; Ho, Gloria Y F; Xue, XiaoNan; Rajpathak, Swapnil; Cushman, Mary; Rohan, Thomas E.; Strickler, Howard D.; Scherer, Philipp E.; Anastos, Kathryn.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 6, 01.06.2007, p. 1291-1293.

Research output: Contribution to journalArticle

Kaplan, RC, Ho, GYF, Xue, X, Rajpathak, S, Cushman, M, Rohan, TE, Strickler, HD, Scherer, PE & Anastos, K 2007, 'Within-individual stability of obesity-related biomarkers among women', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 6, pp. 1291-1293. https://doi.org/10.1158/1055-9965.EPI-06-1089
Kaplan, Robert C. ; Ho, Gloria Y F ; Xue, XiaoNan ; Rajpathak, Swapnil ; Cushman, Mary ; Rohan, Thomas E. ; Strickler, Howard D. ; Scherer, Philipp E. ; Anastos, Kathryn. / Within-individual stability of obesity-related biomarkers among women. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 6. pp. 1291-1293.
@article{d80e7de48c1c49c99ee14e64e3f77370,
title = "Within-individual stability of obesity-related biomarkers among women",
abstract = "Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested. Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor α, interleukin 6, and insulin among healthy young women. Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other race/ethnicity) with mean age of 32.3 years, mean body mass index of 31.2 kg/m2, and 76{\%} prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor α (0.39), and interleukin 6 (0.47). Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.",
author = "Kaplan, {Robert C.} and Ho, {Gloria Y F} and XiaoNan Xue and Swapnil Rajpathak and Mary Cushman and Rohan, {Thomas E.} and Strickler, {Howard D.} and Scherer, {Philipp E.} and Kathryn Anastos",
year = "2007",
month = "6",
day = "1",
doi = "10.1158/1055-9965.EPI-06-1089",
language = "English (US)",
volume = "16",
pages = "1291--1293",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Within-individual stability of obesity-related biomarkers among women

AU - Kaplan, Robert C.

AU - Ho, Gloria Y F

AU - Xue, XiaoNan

AU - Rajpathak, Swapnil

AU - Cushman, Mary

AU - Rohan, Thomas E.

AU - Strickler, Howard D.

AU - Scherer, Philipp E.

AU - Anastos, Kathryn

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested. Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor α, interleukin 6, and insulin among healthy young women. Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other race/ethnicity) with mean age of 32.3 years, mean body mass index of 31.2 kg/m2, and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor α (0.39), and interleukin 6 (0.47). Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.

AB - Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested. Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor α, interleukin 6, and insulin among healthy young women. Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other race/ethnicity) with mean age of 32.3 years, mean body mass index of 31.2 kg/m2, and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor α (0.39), and interleukin 6 (0.47). Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.

UR - http://www.scopus.com/inward/record.url?scp=34250893340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250893340&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-06-1089

DO - 10.1158/1055-9965.EPI-06-1089

M3 - Article

VL - 16

SP - 1291

EP - 1293

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 6

ER -