WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Sachith Gallolu Kankanamalage, Aroon S. Karra, Melanie H Cobb

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters. Main body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Conclusion: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.

Original languageEnglish (US)
Article number72
JournalCell Communication and Signaling
Volume16
Issue number1
DOIs
StatePublished - Nov 3 2018

Keywords

  • And NF-κB
  • Cancer
  • Cellular signaling
  • Ion transport
  • OSR1
  • PI3K-AKT
  • SPAK
  • STK39
  • TGF-β
  • WNKs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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