WNK1: Analysis of protein kinase structure, downstream targets, and potential roles in hypertension

Bing E. Xu, Byung Hoon Lee, Xiaoshan Min, Lisa Lenertz, Charles J. Heise, Steve Stippec, Elizabeth J. Goldsmith, Melanie H. Cobb

Research output: Contribution to journalShort survey

44 Scopus citations

Abstract

The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This review focuses on the recent evidence elucidating the structure of the kinase domain of WNK1 and functions of these kinases in normal and disease physiology. Their functions have implications for understanding the biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. The WNK kinases may be able to influence ion homeostasis through its effects on synaptotagmin function.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalCell Research
Volume15
Issue number1
DOIs
StatePublished - Nov 28 2005

Keywords

  • ERK5
  • Hypertension
  • Kinase
  • MAP3K
  • MAP4K
  • RNAi
  • Synaptotagmin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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