Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos

Christian E. Rocheleau, William D. Downs, Rueyling Lin, Claudia Wittmann, Yanxia Bei, Yoon Hee Cha, Mussa Ali, James R. Priess, Craig C. Mello

Research output: Contribution to journalArticle

502 Citations (Scopus)

Abstract

In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/ Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/ wingless, porcupine, frizzled, β-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalCell
Volume90
Issue number4
DOIs
StatePublished - Aug 22 1997

Fingerprint

APC Genes
Endoderm
Blastomeres
Embryonic Structures
Genes
Porcupines
Armadillos
Reverse Genetics
Catenins
Wnt Signaling Pathway
Set theory
Specifications

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y. H., ... Mello, C. C. (1997). Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell, 90(4), 707-716. https://doi.org/10.1016/S0092-8674(00)80531-0

Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. / Rocheleau, Christian E.; Downs, William D.; Lin, Rueyling; Wittmann, Claudia; Bei, Yanxia; Cha, Yoon Hee; Ali, Mussa; Priess, James R.; Mello, Craig C.

In: Cell, Vol. 90, No. 4, 22.08.1997, p. 707-716.

Research output: Contribution to journalArticle

Rocheleau, CE, Downs, WD, Lin, R, Wittmann, C, Bei, Y, Cha, YH, Ali, M, Priess, JR & Mello, CC 1997, 'Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos', Cell, vol. 90, no. 4, pp. 707-716. https://doi.org/10.1016/S0092-8674(00)80531-0
Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH et al. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997 Aug 22;90(4):707-716. https://doi.org/10.1016/S0092-8674(00)80531-0
Rocheleau, Christian E. ; Downs, William D. ; Lin, Rueyling ; Wittmann, Claudia ; Bei, Yanxia ; Cha, Yoon Hee ; Ali, Mussa ; Priess, James R. ; Mello, Craig C. / Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. In: Cell. 1997 ; Vol. 90, No. 4. pp. 707-716.
@article{5b44e5786a40457883adcece5aa00155,
title = "Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos",
abstract = "In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/ Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/ wingless, porcupine, frizzled, β-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.",
author = "Rocheleau, {Christian E.} and Downs, {William D.} and Rueyling Lin and Claudia Wittmann and Yanxia Bei and Cha, {Yoon Hee} and Mussa Ali and Priess, {James R.} and Mello, {Craig C.}",
year = "1997",
month = "8",
day = "22",
doi = "10.1016/S0092-8674(00)80531-0",
language = "English (US)",
volume = "90",
pages = "707--716",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos

AU - Rocheleau, Christian E.

AU - Downs, William D.

AU - Lin, Rueyling

AU - Wittmann, Claudia

AU - Bei, Yanxia

AU - Cha, Yoon Hee

AU - Ali, Mussa

AU - Priess, James R.

AU - Mello, Craig C.

PY - 1997/8/22

Y1 - 1997/8/22

N2 - In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/ Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/ wingless, porcupine, frizzled, β-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.

AB - In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/ Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/ wingless, porcupine, frizzled, β-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.

UR - http://www.scopus.com/inward/record.url?scp=0030829387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030829387&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(00)80531-0

DO - 10.1016/S0092-8674(00)80531-0

M3 - Article

C2 - 9288750

AN - SCOPUS:0030829387

VL - 90

SP - 707

EP - 716

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -