@article{9b02fd4e64ce446a89f074c426390b2e,
title = "WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature",
abstract = "Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions-including cell death-in adjacent cells, and raise the possibility that they do so in many different cellular contexts.",
author = "Lobov, {Ivan B.} and Sujata Rao and Carroll, {Thomas J.} and Vallance, {Jefferson E.} and Masataka Ito and Ondr, {Jennifer K.} and Savita Kurup and Glass, {Donald A.} and Patel, {Millan S.} and Weiguo Shu and Morrisey, {Edward E.} and McMahon, {Andrew P.} and Gerard Karsenty and Lang, {Richard A.}",
note = "Funding Information: Acknowledgements We thank: P. Speeg for technical assistance; E. Fuchs, L. Niswander and C. Dean for the TOPGAL mice; S. McKercher and R. Maki for the PU.1-null mice; L. Chan for the Lrp5-null mice; and, R. Grosschedl for the Lef1-null mice. We are indebted to Q. Xu and J. Nathans for providing the SuperTOPFLASH cell line and for the Fzd and Norrin expression plasmids. This work was supported by NIH grants to E.E.M., A.P.M., G.K. and R.A.L. G.K. was also supported by funds from the March of Dimes, and R.A.L. by funds from the Abrahamson Pediatric Eye Institute Endowment at the Children{\textquoteright}s Hospital Medical Center of Cincinnati.",
year = "2005",
month = sep,
day = "15",
doi = "10.1038/nature03928",
language = "English (US)",
volume = "437",
pages = "417--421",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7057",
}