WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

Ivan B. Lobov, Sujata Rao, Thomas J. Carroll, Jefferson E. Vallance, Masataka Ito, Jennifer K. Ondr, Savita Kurup, Donald A. Glass, Millan S. Patel, Weiguo Shu, Edward E. Morrisey, Andrew P. McMahon, Gerard Karsenty, Richard A. Lang

Research output: Contribution to journalArticle

299 Scopus citations

Abstract

Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions-including cell death-in adjacent cells, and raise the possibility that they do so in many different cellular contexts.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalNature
Volume437
Issue number7057
DOIs
Publication statusPublished - Sep 15 2005

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Lobov, I. B., Rao, S., Carroll, T. J., Vallance, J. E., Ito, M., Ondr, J. K., ... Lang, R. A. (2005). WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature, 437(7057), 417-421. https://doi.org/10.1038/nature03928