Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system

Thomas J. Carroll, Joo Seop Park, Shigemi Hayashi, Arindam Majumdar, Andrew P. McMahon

Research output: Contribution to journalArticle

539 Citations (Scopus)

Abstract

The vertebrate urogenital system forms due to inductive interactions between the Wolffian duct, its derivative the ureteric bud, and their adjacent mesenchymes. These establish epithelial primordia within the mesonephric (embryonic) and metanephric (adult) kidneys and the Müllerian duct, the anlage of much of the female reproductive tract. We show that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct. Wnt9b is required for the earliest inductive response in metanephric mesenchyme. Further, Wnt9b-expressing cells can functionally substitute for the ureteric bud in these interactions. Wnt9b acts upstream of another Wnt, Wnt4, in this process, and our data implicate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urogenital system. Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalDevelopmental Cell
Volume9
Issue number2
DOIs
StatePublished - Aug 2005

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Urogenital System
Epithelial-Mesenchymal Transition
Organogenesis
Ducts
Mesoderm
Wolffian Ducts
Vertebrates
Epithelium
Derivatives
Kidney

ASJC Scopus subject areas

  • Developmental Biology

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Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. / Carroll, Thomas J.; Park, Joo Seop; Hayashi, Shigemi; Majumdar, Arindam; McMahon, Andrew P.

In: Developmental Cell, Vol. 9, No. 2, 08.2005, p. 283-292.

Research output: Contribution to journalArticle

Carroll, Thomas J. ; Park, Joo Seop ; Hayashi, Shigemi ; Majumdar, Arindam ; McMahon, Andrew P. / Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. In: Developmental Cell. 2005 ; Vol. 9, No. 2. pp. 283-292.
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