TY - JOUR
T1 - Worsening hypertriglyceridemia with oral contraceptive pills in an adolescent with HIV-associated lipodystrophy
T2 - A case report and review of the literature
AU - Patni, Nivedita
AU - Diaz, Elizabeth G.Lipman
AU - Cabral, Maria Demma
AU - Siqueira, Lorena M.
AU - Diaz, Alejandro
N1 - Publisher Copyright:
© by De Gruyter 2014.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - We report a case of a 17-year-old girl with a history of congenital human immunodeficiency virus (HIV) infection and lipodystrophy secondary to highly active antiretroviral therapy (HAART). She developed severe worsening of preexisting hypertriglyceridemia after treatment with oral contraceptive pills (OCP) for polycystic ovary syndrome. Her hypertriglyceridemia improved upon OCP discontinuation. Although it is known that estrogen combined with progestins have a negative effect on triglycerides and high-density lipoprotein (HDL) cholesterol levels, to our knowledge the association of HAART-related lipodystrophy and severe hypertriglyceridemia after OCP use has not been reported in the literature. We recommend avoiding the use of OCPs in patients with lipodystrophy due to the increased risk of worsening hypertriglyceridemia.
AB - We report a case of a 17-year-old girl with a history of congenital human immunodeficiency virus (HIV) infection and lipodystrophy secondary to highly active antiretroviral therapy (HAART). She developed severe worsening of preexisting hypertriglyceridemia after treatment with oral contraceptive pills (OCP) for polycystic ovary syndrome. Her hypertriglyceridemia improved upon OCP discontinuation. Although it is known that estrogen combined with progestins have a negative effect on triglycerides and high-density lipoprotein (HDL) cholesterol levels, to our knowledge the association of HAART-related lipodystrophy and severe hypertriglyceridemia after OCP use has not been reported in the literature. We recommend avoiding the use of OCPs in patients with lipodystrophy due to the increased risk of worsening hypertriglyceridemia.
KW - highly active antiretroviral therapy
KW - human immunodeficiency virus
KW - hypertriglyceridemia
KW - polycystic ovary syndrome
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U2 - 10.1515/jpem-2013-0437
DO - 10.1515/jpem-2013-0437
M3 - Article
C2 - 24859501
AN - SCOPUS:84922186622
SN - 0334-018X
VL - 27
SP - 1247
EP - 1251
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 11-12
ER -