Wrestling with native chemical ligation

Hagan Bayley, Stephen Cheley, Leon Harrington, Ruhma Syeda

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalACS chemical biology
Issue number12
StatePublished - Dec 18 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine


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