Wrestling with native chemical ligation

Hagan Bayley; Stephen Cheley; Leon Harrington; Ruhma Syeda

doi:10.1021/cb900304p

Wrestling with native chemical ligation

Hagan Bayley, Stephen Cheley, Leon Harrington, Ruhma Syeda

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.

Original language	English (US)
Pages (from-to)	983-985
Number of pages	3
Journal	ACS chemical biology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/cb900304p
State	Published - Dec 18 2009

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

Access to Document

10.1021/cb900304p

Cite this

@article{f53dff38176546ad8b8bf319cdf6d73d,

title = "Wrestling with native chemical ligation",

abstract = "An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.",

author = "Hagan Bayley and Stephen Cheley and Leon Harrington and Ruhma Syeda",

year = "2009",

month = dec,

day = "18",

doi = "10.1021/cb900304p",

language = "English (US)",

volume = "4",

pages = "983--985",

journal = "ACS chemical biology",

issn = "1554-8929",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Wrestling with native chemical ligation

AU - Bayley, Hagan

AU - Cheley, Stephen

AU - Harrington, Leon

AU - Syeda, Ruhma

PY - 2009/12/18

Y1 - 2009/12/18

N2 - An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.

AB - An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.

UR - http://www.scopus.com/inward/record.url?scp=73649112743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73649112743&partnerID=8YFLogxK

U2 - 10.1021/cb900304p

DO - 10.1021/cb900304p

M3 - Review article

C2 - 20017575

AN - SCOPUS:73649112743

SN - 1554-8929

VL - 4

SP - 983

EP - 985

JO - ACS chemical biology

JF - ACS chemical biology

IS - 12

ER -

Wrestling with native chemical ligation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this