Abstract
Recent years have brought not only an avalanche of new macromolecular structures, but also significant advances in the protein structure determination methodology only now making its way into structure-based drug discovery. In this chapter, we review recent methodology developments in X-ray diffraction experiments that led to fast and very accurate elucidation of three-dimensional structures of macromolecules. We will discuss the role of data collection as the last experiment performed in the crystal structure determination process. A statistical analysis of diffraction experiments that are reported in the Protein Data Bank (PDB) is also presented.
Original language | English (US) |
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Pages (from-to) | 23-40 |
Number of pages | 18 |
Journal | Advances in Protein Chemistry and Structural Biology |
Volume | 77 |
State | Published - 2009 |
ASJC Scopus subject areas
- Biochemistry
- Structural Biology