X-ray excited ZnS: Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma, Xiaoju Zou, Brian Bui, Wei Chen, Kwang Hyun Song, Timothy Solberg

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

Original languageEnglish (US)
Article number013702
JournalApplied Physics Letters
Volume105
Issue number1
DOIs
StatePublished - Jul 7 2014

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afterglows
activation
nanoparticles
toxicity
therapy
x rays
light sources
cobalt
cancer
energy transfer
luminescence
copper

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Ma, L., Zou, X., Bui, B., Chen, W., Song, K. H., & Solberg, T. (2014). X-ray excited ZnS: Cu,Co afterglow nanoparticles for photodynamic activation. Applied Physics Letters, 105(1), [013702]. https://doi.org/10.1063/1.4890105

X-ray excited ZnS : Cu,Co afterglow nanoparticles for photodynamic activation. / Ma, Lun; Zou, Xiaoju; Bui, Brian; Chen, Wei; Song, Kwang Hyun; Solberg, Timothy.

In: Applied Physics Letters, Vol. 105, No. 1, 013702, 07.07.2014.

Research output: Contribution to journalArticle

Ma, L, Zou, X, Bui, B, Chen, W, Song, KH & Solberg, T 2014, 'X-ray excited ZnS: Cu,Co afterglow nanoparticles for photodynamic activation', Applied Physics Letters, vol. 105, no. 1, 013702. https://doi.org/10.1063/1.4890105
Ma, Lun ; Zou, Xiaoju ; Bui, Brian ; Chen, Wei ; Song, Kwang Hyun ; Solberg, Timothy. / X-ray excited ZnS : Cu,Co afterglow nanoparticles for photodynamic activation. In: Applied Physics Letters. 2014 ; Vol. 105, No. 1.
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