Xanthine oxidase contributes to lung leak in rats subjected to skin burn

Lisa K. Burton; Stephen E. Velasco; Anita Patt; Lance S. Terada; John E. Repine

doi:10.1007/BF01534378

Xanthine oxidase contributes to lung leak in rats subjected to skin burn

Lisa K. Burton, Stephen E. Velasco, Anita Patt, Lance S. Terada, John E. Repine

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16 Scopus citations

Abstract

We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH₅₀ levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.

Original language	English (US)
Pages (from-to)	31-38
Number of pages	8
Journal	Inflammation
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/BF01534378
State	Published - Feb 1995

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Xanthine oxidase contributes to lung leak in rats subjected to skin burn",

abstract = "We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH50 levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.",

author = "Burton, {Lisa K.} and Velasco, {Stephen E.} and Anita Patt and Terada, {Lance S.} and Repine, {John E.}",

year = "1995",

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doi = "10.1007/BF01534378",

language = "English (US)",

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T1 - Xanthine oxidase contributes to lung leak in rats subjected to skin burn

AU - Burton, Lisa K.

AU - Velasco, Stephen E.

AU - Patt, Anita

AU - Terada, Lance S.

AU - Repine, John E.

PY - 1995/2

Y1 - 1995/2

N2 - We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH50 levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.

AB - We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH50 levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.

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Xanthine oxidase contributes to lung leak in rats subjected to skin burn

Abstract

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