Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M. L. Waintrub, L. S. Terada, C. J. Beehler, B. O. Anderson, J. A. Leff, J. E. Repine

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

Original languageEnglish (US)
Pages (from-to)1755-1757
Number of pages3
JournalJournal of applied physiology
Volume68
Issue number4
StatePublished - Jan 1 1990

Keywords

  • lung albumin uptake
  • oxygen radicals
  • vascular injury
  • xanthine dehydrogenase activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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