Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M. L. Waintrub; L. S. Terada; C. J. Beehler; B. O. Anderson; J. A. Leff; J. E. Repine

Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M. L. Waintrub, L. S. Terada, C. J. Beehler, B. O. Anderson, J. A. Leff, J. E. Repine

Research output: Contribution to journal › Article › peer-review

Abstract

Two lines of investigation suggested that xanthine oxidase- (XO) derived O₂ metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

Original language	English (US)
Pages (from-to)	1755-1757
Number of pages	3
Journal	Journal of applied physiology
Volume	68
Issue number	4
State	Published - Jan 1 1990

Keywords

lung albumin uptake
oxygen radicals
vascular injury
xanthine dehydrogenase activity

ASJC Scopus subject areas

Physiology
Physiology (medical)

Cite this

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title = "Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury",

abstract = "Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.",

keywords = "lung albumin uptake, oxygen radicals, vascular injury, xanthine dehydrogenase activity",

author = "Waintrub, {M. L.} and Terada, {L. S.} and Beehler, {C. J.} and Anderson, {B. O.} and Leff, {J. A.} and Repine, {J. E.}",

year = "1990",

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language = "English (US)",

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T1 - Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

AU - Waintrub, M. L.

AU - Terada, L. S.

AU - Beehler, C. J.

AU - Anderson, B. O.

AU - Leff, J. A.

AU - Repine, J. E.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

AB - Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

KW - lung albumin uptake

KW - oxygen radicals

KW - vascular injury

KW - xanthine dehydrogenase activity

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M3 - Article

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AN - SCOPUS:0025266336

SN - 0161-7567

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JO - Journal of applied physiology

JF - Journal of applied physiology

IS - 4

ER -

Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

Abstract

Keywords

ASJC Scopus subject areas

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