TY - JOUR
T1 - Xenobiotic metabolism in the fourth dimension
T2 - PARtners in time
AU - Green, Carla B.
AU - Takahashi, Joseph S.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/7
Y1 - 2006/7
N2 - A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.
AB - A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.
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U2 - 10.1016/j.cmet.2006.06.002
DO - 10.1016/j.cmet.2006.06.002
M3 - Short survey
C2 - 16814725
AN - SCOPUS:33745397720
SN - 1550-4131
VL - 4
SP - 3
EP - 4
JO - Cell Metabolism
JF - Cell Metabolism
IS - 1
ER -