Xenobiotic metabolism in the fourth dimension

PARtners in time

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalCell Metabolism
Volume4
Issue number1
DOIs
StatePublished - Jul 2006

Fingerprint

Circadian Clocks
Xenobiotics
Basic-Leucine Zipper Transcription Factors
Premature Aging
Transcriptome
Mammals
Hypersensitivity
Kidney
Gene Expression
Liver
Pharmaceutical Preparations
Genes
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Xenobiotic metabolism in the fourth dimension : PARtners in time. / Green, Carla B.; Takahashi, Joseph S.

In: Cell Metabolism, Vol. 4, No. 1, 07.2006, p. 3-4.

Research output: Contribution to journalArticle

@article{ba4d2478d5064b67ac371e3005c1d4ca,
title = "Xenobiotic metabolism in the fourth dimension: PARtners in time",
abstract = "A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.",
author = "Green, {Carla B.} and Takahashi, {Joseph S.}",
year = "2006",
month = "7",
doi = "10.1016/j.cmet.2006.06.002",
language = "English (US)",
volume = "4",
pages = "3--4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Xenobiotic metabolism in the fourth dimension

T2 - PARtners in time

AU - Green, Carla B.

AU - Takahashi, Joseph S.

PY - 2006/7

Y1 - 2006/7

N2 - A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.

AB - A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.

UR - http://www.scopus.com/inward/record.url?scp=33745397720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745397720&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2006.06.002

DO - 10.1016/j.cmet.2006.06.002

M3 - Article

VL - 4

SP - 3

EP - 4

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -