Xenotransplantation and Kidney Regenerative Technology

Kazuhiko Yamada, Masayuki Tasaki, Adam Griesemar, Jigesh Shah

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The disparity between available donor organs and an increasing recipient waitlist has prompted significant research into alternative avenues to meet this growing demand. Potential options include renal regenerative medicine through the use of various cell-based therapies as well as de-novo organ generation via bioengineered scaffolds. Conversely, xenotransplantation, utilizing pigs as source for potential donor organs, remains a more promising option once specific xenogeneic related immunologic, physiologic, and infectious barriers can be resolved. Reviews of the most recent advances that are available for both renal regeneration as well as renal xenotransplantation are provided in this chapter.

Original languageEnglish (US)
Title of host publicationKidney Transplantation, Bioengineering, and Regeneration
Subtitle of host publicationKidney Transplantation in the Regenerative Medicine Era
PublisherElsevier Inc.
Pages1151-1161
Number of pages11
ISBN (Electronic)9780128018361
ISBN (Print)9780128017340
DOIs
StatePublished - Jul 6 2017
Externally publishedYes

Keywords

  • Blastocyst complementation
  • De-novo organ generation
  • Immunology of xenografts
  • Metanephros of growing xenoembryos
  • Transgenic swine donors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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