TY - JOUR
T1 - Xenotransplantation
T2 - Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials
AU - Yamada, Kazuhiko
AU - Shah, Jigesh A.
AU - Tanabe, Tatsu
AU - Lanaspa, Miguel A.
AU - Johnson, Richard J.
N1 - Funding Information:
The authors would like to thank Dr. David H. Sachs for his helpful advice and review of this manuscript. Our research described in this review article was supported by NIH grant P01 AI045897.
Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose: Interspecies transplantation, xenotransplantation, is becoming a realistic strategy to solve the organ shortage crisis. Here, we focus on seminal publications that have driven research in xenotransplantation, as well as recently published literature and future endeavors. Recent Findings: Advances in gene editing technology have allowed for the efficient production of multitransgenic porcine donors leading improved xenograft survival in baboons, up to 2 years following heterotopic heart xenotransplantation and from weeks to several months following life-supporting kidney xenotransplanation. As technology evolves, additional challenges have arisen, including the development of proteinuria, early graft loss associated with porcine CMV, disparities in organ growth between donors and recipients, as well as high-dose continuous immunosuppression requirements. To address these issues, our laboratory developed a tolerance-inducing protocol which has allowed for >6-month survival of a life-supporting kidney with further approaches currently underway to address the challenges mentioned above. Summary: Our recent findings, reviewed in this article, led us to develop methods to overcome obstacles, which, in conjunction with the work of others, are promising for future clinical applications of xenotransplantation.
AB - Purpose: Interspecies transplantation, xenotransplantation, is becoming a realistic strategy to solve the organ shortage crisis. Here, we focus on seminal publications that have driven research in xenotransplantation, as well as recently published literature and future endeavors. Recent Findings: Advances in gene editing technology have allowed for the efficient production of multitransgenic porcine donors leading improved xenograft survival in baboons, up to 2 years following heterotopic heart xenotransplantation and from weeks to several months following life-supporting kidney xenotransplanation. As technology evolves, additional challenges have arisen, including the development of proteinuria, early graft loss associated with porcine CMV, disparities in organ growth between donors and recipients, as well as high-dose continuous immunosuppression requirements. To address these issues, our laboratory developed a tolerance-inducing protocol which has allowed for >6-month survival of a life-supporting kidney with further approaches currently underway to address the challenges mentioned above. Summary: Our recent findings, reviewed in this article, led us to develop methods to overcome obstacles, which, in conjunction with the work of others, are promising for future clinical applications of xenotransplantation.
KW - Gene manipulation
KW - Kidney transplantation
KW - Pigs
KW - Proteinuria
KW - Tolerance
KW - Xenotransplantation
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U2 - 10.1007/s40472-017-0149-6
DO - 10.1007/s40472-017-0149-6
M3 - Article
C2 - 28989853
AN - SCOPUS:85048634962
SN - 2196-3029
VL - 4
SP - 101
EP - 109
JO - Current Transplantation Reports
JF - Current Transplantation Reports
IS - 2
ER -