Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials

Kazuhiko Yamada, Jigesh A. Shah, Tatsu Tanabe, Miguel A. Lanaspa, Richard J. Johnson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: Interspecies transplantation, xenotransplantation, is becoming a realistic strategy to solve the organ shortage crisis. Here, we focus on seminal publications that have driven research in xenotransplantation, as well as recently published literature and future endeavors. Recent Findings: Advances in gene editing technology have allowed for the efficient production of multitransgenic porcine donors leading improved xenograft survival in baboons, up to 2 years following heterotopic heart xenotransplantation and from weeks to several months following life-supporting kidney xenotransplanation. As technology evolves, additional challenges have arisen, including the development of proteinuria, early graft loss associated with porcine CMV, disparities in organ growth between donors and recipients, as well as high-dose continuous immunosuppression requirements. To address these issues, our laboratory developed a tolerance-inducing protocol which has allowed for >6-month survival of a life-supporting kidney with further approaches currently underway to address the challenges mentioned above. Summary: Our recent findings, reviewed in this article, led us to develop methods to overcome obstacles, which, in conjunction with the work of others, are promising for future clinical applications of xenotransplantation.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalCurrent Transplantation Reports
Volume4
Issue number2
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Keywords

  • Gene manipulation
  • Kidney transplantation
  • Pigs
  • Proteinuria
  • Tolerance
  • Xenotransplantation

ASJC Scopus subject areas

  • Transplantation
  • Surgery
  • Hepatology
  • Nephrology
  • Immunology

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