Yb-DTPA, a novel contrast agent in magnetic resonance imaging: Application to rat kidney

S. K. Sarkar, R. E. Rycyna, R. E. Lenkinski, H. A. Solleveld, L. B. Kinter

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Abstract

We have developed a novel contrast agent, ytterbium-diethylenetriamine pentaacetic acid (Yb-DTPA), for magnetic resonance imaging (MRI) and its mechanism of action is predominantly by the susceptibility mechanism. We have applied this contrast agent for renal MRI studies. We also demonstrate that Yb-DTPA has a renal clearance similar to that of inulin in rats and may therefore be useful for the estimation of glomerular filtration rate.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalMagnetic Resonance in Medicine
Volume17
Issue number2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sarkar, S. K., Rycyna, R. E., Lenkinski, R. E., Solleveld, H. A., & Kinter, L. B. (1991). Yb-DTPA, a novel contrast agent in magnetic resonance imaging: Application to rat kidney. Magnetic Resonance in Medicine, 17(2), 328-335.