Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Yu San Yang, Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P. Tu

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

Original languageEnglish (US)
Pages (from-to)697-710.e17
JournalCell
Volume177
Issue number3
DOIs
StatePublished - Apr 18 2019

Keywords

  • Ataxin-2
  • Autophagy
  • Low-complexity sequence
  • Pbp1
  • TORC1
  • cross-β
  • gel
  • mitochondria
  • phase separation
  • polymer
  • respiration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Yang, Y. S., Kato, M., Wu, X., Litsios, A., Sutter, B. M., Wang, Y., Hsu, C. H., Wood, N. E., Lemoff, A., Mirzaei, H., Heinemann, M., & Tu, B. P. (2019). Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth. Cell, 177(3), 697-710.e17. https://doi.org/10.1016/j.cell.2019.02.043