Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Yu San Yang, Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P Tu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

Original languageEnglish (US)
Pages (from-to)697-710.e17
JournalCell
Volume177
Issue number3
DOIs
Publication statusPublished - Apr 18 2019

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Keywords

  • Ataxin-2
  • Autophagy
  • cross-β
  • gel
  • Low-complexity sequence
  • mitochondria
  • Pbp1
  • phase separation
  • polymer
  • respiration
  • TORC1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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