Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Yu San Yang; Masato Kato; Xi Wu; Athanasios Litsios; Benjamin M. Sutter; Yun Wang; Chien Hsiang Hsu; N. Ezgi Wood; Andrew Lemoff; Hamid Mirzaei; Matthias Heinemann; Benjamin P. Tu

doi:10.1016/j.cell.2019.02.043

Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Yu San Yang, Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P. Tu

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

Original language	English (US)
Pages (from-to)	697-710.e17
Journal	Cell
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.02.043
State	Published - Apr 18 2019

Keywords

Ataxin-2
Autophagy
Low-complexity sequence
Pbp1
TORC1
cross-β
gel
mitochondria
phase separation
polymer
respiration

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2019.02.043

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title = "Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth",

abstract = "Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.",

keywords = "Ataxin-2, Autophagy, Low-complexity sequence, Pbp1, TORC1, cross-β, gel, mitochondria, phase separation, polymer, respiration",

author = "Yang, {Yu San} and Masato Kato and Xi Wu and Athanasios Litsios and Sutter, {Benjamin M.} and Yun Wang and Hsu, {Chien Hsiang} and Wood, {N. Ezgi} and Andrew Lemoff and Hamid Mirzaei and Matthias Heinemann and Tu, {Benjamin P.}",

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year = "2019",

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day = "18",

doi = "10.1016/j.cell.2019.02.043",

language = "English (US)",

volume = "177",

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T1 - Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

AU - Yang, Yu San

AU - Kato, Masato

AU - Wu, Xi

AU - Litsios, Athanasios

AU - Sutter, Benjamin M.

AU - Wang, Yun

AU - Hsu, Chien Hsiang

AU - Wood, N. Ezgi

AU - Lemoff, Andrew

AU - Mirzaei, Hamid

AU - Heinemann, Matthias

AU - Tu, Benjamin P.

PY - 2019/4/18

Y1 - 2019/4/18

N2 - Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

AB - Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

KW - Ataxin-2

KW - Autophagy

KW - Low-complexity sequence

KW - Pbp1

KW - TORC1

KW - cross-β

KW - gel

KW - mitochondria

KW - phase separation

KW - polymer

KW - respiration

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DO - 10.1016/j.cell.2019.02.043

M3 - Article

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AN - SCOPUS:85064258741

SN - 0092-8674

VL - 177

SP - 697-710.e17

JO - Cell

JF - Cell

IS - 3

ER -

Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Abstract

Keywords

ASJC Scopus subject areas

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