Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth

Yu San Yang, Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P Tu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.

Original languageEnglish (US)
Pages (from-to)697-710.e17
JournalCell
Volume177
Issue number3
DOIs
StatePublished - Apr 18 2019

Fingerprint

Phase Transition
Yeast
Homeostasis
Yeasts
Phase transitions
Growth
mechanistic target of rapamycin complex 1
Ataxin-2

Keywords

  • Ataxin-2
  • Autophagy
  • cross-β
  • gel
  • Low-complexity sequence
  • mitochondria
  • Pbp1
  • phase separation
  • polymer
  • respiration
  • TORC1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth. / Yang, Yu San; Kato, Masato; Wu, Xi; Litsios, Athanasios; Sutter, Benjamin M.; Wang, Yun; Hsu, Chien Hsiang; Wood, N. Ezgi; Lemoff, Andrew; Mirzaei, Hamid; Heinemann, Matthias; Tu, Benjamin P.

In: Cell, Vol. 177, No. 3, 18.04.2019, p. 697-710.e17.

Research output: Contribution to journalArticle

Yang, YS, Kato, M, Wu, X, Litsios, A, Sutter, BM, Wang, Y, Hsu, CH, Wood, NE, Lemoff, A, Mirzaei, H, Heinemann, M & Tu, BP 2019, 'Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth', Cell, vol. 177, no. 3, pp. 697-710.e17. https://doi.org/10.1016/j.cell.2019.02.043
Yang, Yu San ; Kato, Masato ; Wu, Xi ; Litsios, Athanasios ; Sutter, Benjamin M. ; Wang, Yun ; Hsu, Chien Hsiang ; Wood, N. Ezgi ; Lemoff, Andrew ; Mirzaei, Hamid ; Heinemann, Matthias ; Tu, Benjamin P. / Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth. In: Cell. 2019 ; Vol. 177, No. 3. pp. 697-710.e17.
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