TY - JOUR
T1 - Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism
AU - Yoon, Sara
AU - Liu, Zhengchang
AU - Eyobo, Yvonne
AU - Orth, Kim
PY - 2003/1/24
Y1 - 2003/1/24
N2 - Yersinia effector, YopJ, inhibits the innate immune response by blocking MAP kinase and NFκB signaling pathways in mammalian cells. Herein, YopJ is shown to disrupt the MAP kinase signaling pathways in Saccharomyces cerevisiae. Expression of YopJ in yeast blocks the ability of yeast to respond to α factor by disrupting activation of the pheromone signaling pathway upstream of the activation of the MAPK Fus3p. YopJ also blocks the high osmolarity growth (HOG) MAP kinase pathway in yeast upstream of the activation of the MAPK Hog1p. YopJ is proposed to block the MAP kinase pathways in yeast in a similar manner to the way it blocks mammalian signaling pathways, implicating that a novel, evolutionarily conserved mechanism of regulation is utilized for signal transduction by these pathways.
AB - Yersinia effector, YopJ, inhibits the innate immune response by blocking MAP kinase and NFκB signaling pathways in mammalian cells. Herein, YopJ is shown to disrupt the MAP kinase signaling pathways in Saccharomyces cerevisiae. Expression of YopJ in yeast blocks the ability of yeast to respond to α factor by disrupting activation of the pheromone signaling pathway upstream of the activation of the MAPK Fus3p. YopJ also blocks the high osmolarity growth (HOG) MAP kinase pathway in yeast upstream of the activation of the MAPK Hog1p. YopJ is proposed to block the MAP kinase pathways in yeast in a similar manner to the way it blocks mammalian signaling pathways, implicating that a novel, evolutionarily conserved mechanism of regulation is utilized for signal transduction by these pathways.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037462764&partnerID=8YFLogxK
U2 - 10.1074/jbc.M209905200
DO - 10.1074/jbc.M209905200
M3 - Article
C2 - 12433923
AN - SCOPUS:0037462764
SN - 0021-9258
VL - 278
SP - 2131
EP - 2135
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -