Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism

Sara Yoon, Zhengchang Liu, Yvonne Eyobo, Kim Orth

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Abstract

Yersinia effector, YopJ, inhibits the innate immune response by blocking MAP kinase and NFκB signaling pathways in mammalian cells. Herein, YopJ is shown to disrupt the MAP kinase signaling pathways in Saccharomyces cerevisiae. Expression of YopJ in yeast blocks the ability of yeast to respond to α factor by disrupting activation of the pheromone signaling pathway upstream of the activation of the MAPK Fus3p. YopJ also blocks the high osmolarity growth (HOG) MAP kinase pathway in yeast upstream of the activation of the MAPK Hog1p. YopJ is proposed to block the MAP kinase pathways in yeast in a similar manner to the way it blocks mammalian signaling pathways, implicating that a novel, evolutionarily conserved mechanism of regulation is utilized for signal transduction by these pathways.

Original languageEnglish (US)
Pages (from-to)2131-2135
Number of pages5
JournalJournal of Biological Chemistry
Volume278
Issue number4
DOIs
Publication statusPublished - Jan 24 2003

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ASJC Scopus subject areas

  • Biochemistry

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