Yersinia pseudotuberculosis exploits CD209 receptors for promoting host dissemination and infection

Ying Xia He, Cheng Lin Ye, Pei Zhang, Qiao Li, Chae Gyu Park, Kun Yang, Ling Yu Jiang, Yin Lv, Xiao Ling Ying, Hong Hui Ding, Hong Ping Huang, John Mambwe Tembo, An Yi Li, Bing Cheng, Shu Sheng Zhang, Guo Xing Zheng, Shi Yun Chen, Wei Li, Lian Xu Xia, Biao KanXin Wang, Huai Qi Jing, Rui Fu Yang, Hua Peng, Yang Xin Fu, John D. Klena, Mikael Skurnik, Tie Chena

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Yersinia pseudotuberculosis is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer's patches to initiate dissemination. In this study, we demonstrate that Y. pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These Y. pseudotuberculosis-CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer's patch-deficient mice. The blocking of the Y. pseudotuberculosis-CD209 interactions by expression of O-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for Y. pseudotuberculosis where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the Y. pseudotuberculosis-CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.

Original languageEnglish (US)
Article numbere00654
JournalInfection and immunity
Volume87
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • CD209a
  • CD209b
  • DC-SIGN
  • DCs
  • Dendritic cells
  • Dissemination
  • LPS core
  • Lipopolysaccharide core
  • SIGN-R1
  • Yersinia pseudotuberculosis

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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