You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer

J. W. Shay, H. Werbin, W. E. Wright

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The molecular details of the relationship between cellular senescence and cancer are beginning to emerge. Since telomeres (the ends of the chromosomes) shorten progressively with each cell division, it has been proposed that telomere shortening is the clock that times cellular senescence. The re-expression of telomerase, the enzyme that maintains telomeres and prevents their shortening, occurs in most tumor cells and is probably a critical event in the formation and sustained growth of most cancers.

Original languageEnglish (US)
Pages (from-to)511-524
Number of pages14
JournalCanadian Journal on Aging / La Revue canadienne du vieillissement
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1995

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Keywords

  • Aging
  • Cancer
  • Immortalization
  • Senescence
  • Telomerase
  • Telomeres
  • Télomères
  • cancer
  • immortalité
  • sénescence
  • télomérase
  • vieillissement

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Community and Home Care
  • Geriatrics and Gerontology

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