You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer

J. W. Shay; H. Werbin; W. E. Wright

doi:10.1017/S0714980800009089

You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer

J. W. Shay, H. Werbin, W. E. Wright

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The molecular details of the relationship between cellular senescence and cancer are beginning to emerge. Since telomeres (the ends of the chromosomes) shorten progressively with each cell division, it has been proposed that telomere shortening is the clock that times cellular senescence. The re-expression of telomerase, the enzyme that maintains telomeres and prevents their shortening, occurs in most tumor cells and is probably a critical event in the formation and sustained growth of most cancers.

Original language	English (US)
Pages (from-to)	511-524
Number of pages	14
Journal	Canadian Journal on Aging / La Revue canadienne du vieillissement
Volume	14
Issue number	3
DOIs	https://doi.org/10.1017/S0714980800009089
State	Published - Jan 1 1995

Keywords

Aging
Cancer
Immortalization
Senescence
Telomerase
Telomeres
Télomères
cancer
immortalité
sénescence
télomérase
vieillissement

ASJC Scopus subject areas

Health(social science)
Gerontology
Community and Home Care
Geriatrics and Gerontology

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10.1017/S0714980800009089

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abstract = "The molecular details of the relationship between cellular senescence and cancer are beginning to emerge. Since telomeres (the ends of the chromosomes) shorten progressively with each cell division, it has been proposed that telomere shortening is the clock that times cellular senescence. The re-expression of telomerase, the enzyme that maintains telomeres and prevents their shortening, occurs in most tumor cells and is probably a critical event in the formation and sustained growth of most cancers.",

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KW - Aging

KW - Cancer

KW - Immortalization

KW - Senescence

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KW - télomérase

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You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer

Abstract

Keywords

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