You haven't heard the end of it

Telomere loss may link human aging with cancer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The molecular details of the relationship between cellular senescence and cancer are beginning to emerge. Since telomeres (the ends of the chromosomes) shorten progressively with each cell division, it has been proposed that telomere shortening is the clock that times cellular senescence. The re-expression of telomerase, the enzyme that maintains telomeres and prevents their shortening, occurs in most tumor cells and is probably a critical event in the formation and sustained growth of most cancers.

Original languageEnglish (US)
Pages (from-to)511-524
Number of pages14
JournalCanadian Journal on Aging
Volume14
Issue number3
StatePublished - 1995

Fingerprint

Telomere
cancer
Cell Aging
Telomere Shortening
Neoplasms
Telomerase
Cell Division
event
Chromosomes
Enzymes
Growth
time

Keywords

  • aging
  • cancer
  • immortalization
  • senescence
  • telomerase
  • telomeres

ASJC Scopus subject areas

  • Aging

Cite this

You haven't heard the end of it : Telomere loss may link human aging with cancer. / Shay, J. W.; Werbin, H.; Wright, W. E.

In: Canadian Journal on Aging, Vol. 14, No. 3, 1995, p. 511-524.

Research output: Contribution to journalArticle

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