YY1 functions with INO80 to activate transcription

Yong Cai, Jingji Jin, Tingting Yao, Aaron J. Gottschalk, Selene K. Swanson, Su Wu, Yang Shi, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan W. Conaway

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.

Original languageEnglish (US)
Pages (from-to)872-874
Number of pages3
JournalNature Structural and Molecular Biology
Volume14
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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