ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

Robert T. Williams, Rohiverth Guarecuco, Leah A. Gates, Douglas Barrows, Maria C. Passarelli, Bryce Carey, Lou Baudrier, Swarna Jeewajee, Konnor La, Benjamin Prizer, Sohail Malik, Javier Garcia-Bermudez, Xiphias Ge Zhu, Jason Cantor, Henrik Molina, Thomas Carroll, Robert G. Roeder, Omar Abdel-Wahab, C. David Allis, Kıvanç Birsoy

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Williams et al. identify mediators of the amino acid response pathway in leukemia and demonstrate that ZBTB1 is necessary for cellular proliferation specifically under asparagine deprivation. ZBTB1 associates with the promoter of ASNS and promotes the transcriptional upregulation of ASNS under asparagine deprivation. Loss of ZBTB1 sensitizes leukemic cells to L-asparaginase treatment in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)852-861.e6
JournalCell Metabolism
Volume31
Issue number4
DOIs
StatePublished - Apr 7 2020
Externally publishedYes

Keywords

  • asparaginase
  • ATF4
  • cancer metabolism
  • CRISPR
  • genetic screen
  • leukemia
  • transcription

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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