Abstract
Germ cell tumors (GCTs) are malignant cancers that arise from embryonic precursors known as Primordial Germ Cells. GCTs occur in neonates, children, adolescents and young adults and can occur in the testis, the ovary or extragonadal sites. Because GCTs arise from pluripotent cells, the tumors can exhibit a wide range of different histologies. Current cisplatin-based combination therapies cures most patients, however at the cost of significant toxicity to normal tissues. While GWAS studies and genomic analysis of human GCTs have uncovered somatic mutations and loci that might confer tumor susceptibility, little is still known about the exact mechanisms that drive tumor development, and animal models that faithfully recapitulate all the different GCT subtypes are lacking. Here, we summarize current understanding of germline development in humans and zebrafish, describe the biology of human germ cell tumors, and discuss progress and prospects for zebrafish GCT models that may contribute to better understanding of human GCTs.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 479-494 |
| Number of pages | 16 |
| Volume | 916 |
| DOIs | |
| State | Published - 2016 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 916 |
| ISSN (Print) | 00652598 |
| ISSN (Electronic) | 22148019 |
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Keywords
- Germ cell tumor
- Non-seminoma
- Primordial germ cell
- Seminoma
- Zebrafish
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Zebrafish germ cell tumors. / Sanchez, Angelica; Amatruda, James F.
Advances in Experimental Medicine and Biology. Vol. 916 Springer New York LLC, 2016. p. 479-494 (Advances in Experimental Medicine and Biology; Vol. 916).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Zebrafish germ cell tumors
AU - Sanchez, Angelica
AU - Amatruda, James F.
PY - 2016
Y1 - 2016
N2 - Germ cell tumors (GCTs) are malignant cancers that arise from embryonic precursors known as Primordial Germ Cells. GCTs occur in neonates, children, adolescents and young adults and can occur in the testis, the ovary or extragonadal sites. Because GCTs arise from pluripotent cells, the tumors can exhibit a wide range of different histologies. Current cisplatin-based combination therapies cures most patients, however at the cost of significant toxicity to normal tissues. While GWAS studies and genomic analysis of human GCTs have uncovered somatic mutations and loci that might confer tumor susceptibility, little is still known about the exact mechanisms that drive tumor development, and animal models that faithfully recapitulate all the different GCT subtypes are lacking. Here, we summarize current understanding of germline development in humans and zebrafish, describe the biology of human germ cell tumors, and discuss progress and prospects for zebrafish GCT models that may contribute to better understanding of human GCTs.
AB - Germ cell tumors (GCTs) are malignant cancers that arise from embryonic precursors known as Primordial Germ Cells. GCTs occur in neonates, children, adolescents and young adults and can occur in the testis, the ovary or extragonadal sites. Because GCTs arise from pluripotent cells, the tumors can exhibit a wide range of different histologies. Current cisplatin-based combination therapies cures most patients, however at the cost of significant toxicity to normal tissues. While GWAS studies and genomic analysis of human GCTs have uncovered somatic mutations and loci that might confer tumor susceptibility, little is still known about the exact mechanisms that drive tumor development, and animal models that faithfully recapitulate all the different GCT subtypes are lacking. Here, we summarize current understanding of germline development in humans and zebrafish, describe the biology of human germ cell tumors, and discuss progress and prospects for zebrafish GCT models that may contribute to better understanding of human GCTs.
KW - Germ cell tumor
KW - Non-seminoma
KW - Primordial germ cell
KW - Seminoma
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=84978955019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978955019&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-30654-4_21
DO - 10.1007/978-3-319-30654-4_21
M3 - Chapter
VL - 916
T3 - Advances in Experimental Medicine and Biology
SP - 479
EP - 494
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -