Zebrafish Models of Germ Cell Tumor

Joanie C. Neumann, Kate Lillard, Vanessa Damoulis, James F. Amatruda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Germ cell tumors are neoplasms arising from pluripotent germ cells. In humans, these tumors occur in infants, children and young adults. The tumors display a wide range of histologic differentiation states which exhibit different clinical behaviors. Information about the molecular basis of germ cell tumors, and representative animal models of these neoplasms, are lacking. Germline development in zebrafish and humans is broadly conserved, making the fish a useful model to probe the connections between germ cell development and tumorigenesis. Here, we provide an overview of germline development and a brief review of germ cell tumor biology in humans and zebrafish. We also outline some methods for studying the zebrafish germline.

Original languageEnglish (US)
Pages (from-to)1-24
Number of pages24
JournalMethods in Cell Biology
Volume105
DOIs
StatePublished - 2011

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Germ Cell and Embryonal Neoplasms
Zebrafish
Germ Cells
Neoplasms
Cell Biology
Young Adult
Carcinogenesis
Fishes
Animal Models

Keywords

  • Epigenetic
  • Germ cell
  • Pluripotent
  • Primordial
  • Tumorigenesis
  • Zebrafish

ASJC Scopus subject areas

  • Cell Biology

Cite this

Neumann, J. C., Lillard, K., Damoulis, V., & Amatruda, J. F. (2011). Zebrafish Models of Germ Cell Tumor. Methods in Cell Biology, 105, 1-24. https://doi.org/10.1016/B978-0-12-381320-6.00001-1

Zebrafish Models of Germ Cell Tumor. / Neumann, Joanie C.; Lillard, Kate; Damoulis, Vanessa; Amatruda, James F.

In: Methods in Cell Biology, Vol. 105, 2011, p. 1-24.

Research output: Contribution to journalArticle

Neumann, JC, Lillard, K, Damoulis, V & Amatruda, JF 2011, 'Zebrafish Models of Germ Cell Tumor', Methods in Cell Biology, vol. 105, pp. 1-24. https://doi.org/10.1016/B978-0-12-381320-6.00001-1
Neumann, Joanie C. ; Lillard, Kate ; Damoulis, Vanessa ; Amatruda, James F. / Zebrafish Models of Germ Cell Tumor. In: Methods in Cell Biology. 2011 ; Vol. 105. pp. 1-24.
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