Zebrafish Models of Germ Cell Tumor

Joanie C. Neumann, Kate Lillard, Vanessa Damoulis, James F. Amatruda

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Germ cell tumors are neoplasms arising from pluripotent germ cells. In humans, these tumors occur in infants, children and young adults. The tumors display a wide range of histologic differentiation states which exhibit different clinical behaviors. Information about the molecular basis of germ cell tumors, and representative animal models of these neoplasms, are lacking. Germline development in zebrafish and humans is broadly conserved, making the fish a useful model to probe the connections between germ cell development and tumorigenesis. Here, we provide an overview of germline development and a brief review of germ cell tumor biology in humans and zebrafish. We also outline some methods for studying the zebrafish germline.

Original languageEnglish (US)
Pages (from-to)1-24
Number of pages24
JournalMethods in Cell Biology
Volume105
DOIs
StatePublished - 2011

Keywords

  • Epigenetic
  • Germ cell
  • Pluripotent
  • Primordial
  • Tumorigenesis
  • Zebrafish

ASJC Scopus subject areas

  • Cell Biology

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    Neumann, J. C., Lillard, K., Damoulis, V., & Amatruda, J. F. (2011). Zebrafish Models of Germ Cell Tumor. Methods in Cell Biology, 105, 1-24. https://doi.org/10.1016/B978-0-12-381320-6.00001-1