Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

Sudhir R. Gogu; James S. Malter; Krishna C. Agrawal

doi:10.1016/0006-2952(92)90361-L

Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

Sudhir R. Gogu, James S. Malter, Krishna C. Agrawal

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

Original language	English (US)
Pages (from-to)	1009-1012
Number of pages	4
Journal	Biochemical Pharmacology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/0006-2952(92)90361-L
State	Published - Sep 25 1992

ASJC Scopus subject areas

Biochemistry
Pharmacology

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title = "Zidovudine-induced blockade of the expression and function of the erythropoietin receptor",

abstract = "Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.",

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AU - Gogu, Sudhir R.

AU - Malter, James S.

AU - Agrawal, Krishna C.

PY - 1992/9/25

Y1 - 1992/9/25

N2 - Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

AB - Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

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Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

Abstract

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