Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

Sudhir R. Gogu, James S. Malter, Krishna C. Agrawal

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

Original languageEnglish (US)
Pages (from-to)1009-1012
Number of pages4
JournalBiochemical Pharmacology
Volume44
Issue number6
DOIs
StatePublished - Sep 25 1992

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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