zPoly(D, L-lactide-co-glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

Damon Sutton, Remy Durand, Xintao Shuai, Jinming Gao

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm -1 shifted to 1666 cm -1 as a result of amide bond formation between the two polymers. This was confirmed by 13C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β-lapachone and hydro philic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalJournal of Applied Polymer Science
Volume100
Issue number1
DOIs
Publication statusPublished - Apr 5 2006

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Keywords

  • PH sensitive drug delivery
  • Poly(D,L-lactide-co-glycolide)
  • Poly(ethylenimine)
  • Polymer blends

ASJC Scopus subject areas

  • Polymers and Plastics

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