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2019

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

Yang, T., Dang, Y., Ostaszewski, B., Mengel, D., Steffen, V., Rabe, C., Bittner, T., Walsh, D. M. & Selkoe, D. J., Aug 2019, In : Annals of Neurology. 86, 2, p. 215-224 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2015

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

Yang, T., O'Malley, T. T., Kanmert, D., Jerecic, J., Zieske, L. R., Zetterberg, H., Hyman, B. T., Walsh, D. M. & Selkoe, D. J., 2015, In : Alzheimer's Research and Therapy. 7, 1, 7.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

Hong, S., Ostaszewski, B. L., Yang, T., O'Malley, T. T., Jin, M., Yanagisawa, K., Li, S., Bartels, T. & Selkoe, D. J., Apr 16 2014, In : Neuron. 82, 2, p. 308-319 12 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations
2013

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers

Li, S., Jin, M., Zhang, D., Yang, T., Koeglsperger, T., Fu, H. & Selkoe, D. J., Jan 1 2013, In : Neuron. 77, 5, p. 929-941 13 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

Yang, T., Hong, S., O'Malley, T., Sperling, R. A., Walsh, D. M. & Selkoe, D. J., Mar 1 2013, In : Alzheimer's and Dementia. 9, 2, p. 99-112 14 p.

Research output: Contribution to journalArticle

75 Scopus citations
2012

Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood

Mazumdar, M., Xia, W., Hofmann, O., Gregas, M., Sui, S. H., Hide, W., Yang, T., Needleman, H. L. & Bellinger, D. C., May 2012, In : Environmental Health Perspectives. 120, 5, p. 702-707 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2011

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in isf versus parenchymal aβ during age-related plaque formation

Hong, S., Quintero-Monzon, O., Ostaszewski, B. L., Podlisny, D. R., Cavanaugh, W. T., Yang, T., Holtzman, D. M., Cirrito, J. R. & Selkoe, D. J., Nov 2 2011, In : Journal of Neuroscience. 31, 44, p. 15861-15869 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D. & Selkoe, D. J., Apr 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5819-5824 6 p.

Research output: Contribution to journalArticle

Open Access
525 Scopus citations
2010

Discovery of notch-sparing γ-secretase inhibitors

Augelli-Szafran, C. E., Wei, H. X., Lu, D., Zhang, J., Gu, Y., Yang, T., Osenkowski, P., Ye, W. & Wolfe, M. S., May 1 2010, In : Current Alzheimer Research. 7, 3, p. 207-209 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing γ-secretase inhibitors

Yang, T., Arslanova, D., Xu, X., Li, Y. M. & Xia, W., Jun 1 2010, In : Journal of Neurochemistry. 113, 5, p. 1200-1209 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

Arslanova, D., Yang, T., Xu, X., Wong, S. T., Augelli-Szafran, C. E. & Xia, W., Mar 22 2010, In : BMC Biotechnology. 10, 24.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
2009

A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer Disease

Xia, W., Yang, T., Shankar, G., Smith, I. M., Shen, Y., Walsh, D. M. & Selkoe, D. J., Feb 1 2009, In : Archives of neurology. 66, 2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Open Access
148 Scopus citations

Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains

Baulac, S., Lu, H., Strahle, J., Yang, T., Goldberg, M. S., Shen, J., Schlossmacher, M. G., Lemere, C. A., Lu, Q. & Xia, W., Mar 18 2009, In : Molecular Neurodegeneration. 4, 1, 12.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
2008

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.

Yang, T., Arslanova, D., Gu, Y., Augelli-Szafran, C. & Xia, W., 2008, In : Molecular brain. 1, 1 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations