Cell Biology - Division Y

Research Output

2018

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: A “U-shaped” relationship

Shi, M., Flores, B., Li, P., Gillings, N., McMillan, K. L., Ye, J., Huang, J-S., Sidhu, S. S., Zhong, Y. P., Grompe, M. T., Streeter, P. R., Moe, O. W. & Hu, M. C., Apr 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 4, p. F501-F516

Research output: Contribution to journalArticle

3 Scopus citations

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm

Yao, H., Ma, Y., Hong, Z., Zhao, L., Monaghan, S. A., Hu, M. C. & Huang, J-S., Oct 1 2017, In : Leukemia. 31, 10, p. 2122-2131 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cytokine receptor endocytosis: New kinase activity-dependent and -independent roles of PI3K

Chen, P. H., Yao, H. & Huang, L. J. S., May 1 2017, In : Frontiers in Endocrinology. 8, MAY, 78.

Research output: Contribution to journalArticle

4 Scopus citations

Dynamic change of transcription pausing through modulating NELF protein stability regulates granulocytic differentiation

Liu, X., Gogate, A. A., Tastemel, M., Malladi, V. S., Yao, H., Nguyen, K., Huang, L. J. S. & Bai, X., Aug 8 2017, In : Blood Advances. 1, 18, p. 1358-1367 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

Lu, Z., Xie, J., Wu, G., Shen, J., Collins, R. H., Chen, W., Kang, X., Luo, M., Zou, Y., Huang, J-S., Amatruda, J. F., Slone, T. L., Winick, N. J., Scherer, P. E. & Zhang, C., Dec 12 2016, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

31 Scopus citations

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix

Leroy, E., Dusa, A., Colau, D., Motamedi, A., Cahu, X., Mouton, C., Huang, L. J., Shiau, A. K. & Constantinescu, S. N., Jun 1 2016, In : Biochemical Journal. 473, 11, p. 1579-1591 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2

Dutchak, P. A., Laxman, S., Estill, S. J., Wang, C., Wang, Y., Wang, Y., Bulut, G. B., Gao, J., Huang, L. J. & Tu, B. P., Jul 21 2015, In : Cell Reports. 12, 3, p. 371-379 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Xu, H., He, X., Zheng, H., Huang, L. J., Hou, F., Yu, Z., de la Cruz, M. J., Borkowski, B., Zhang, X., Chen, Z. J. & Jiang, Q. X., Feb 25 2014, In : eLife. 2014, 3, e01489.

Research output: Contribution to journalArticle

95 Scopus citations
2013

Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

Wan, X., Ma, Y., McClendon, C. L., Huang, L. J. S. & Huang, N., Apr 1 2013, In : PLoS Computational Biology. 9, 4, e1003022.

Research output: Contribution to journalArticle

6 Scopus citations

Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis

Bulut, G. B., Sulahian, R., Yao, H. & Huang, L. J. S., Jan 1 2013, In : Blood. 122, 24, p. 3964-3972 9 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity

Kang, C. C., Huang, W. C., Kouh, C. W., Wang, Z. F., Cho, C. C., Chang, C. C., Wang, C. L., Chang, T. C., Seemann, J. & Huang, L. J. S., Oct 1 2013, In : Integrative Biology (United Kingdom). 5, 10, p. 1217-1228 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection

Hu, M. C., Shi, M., Cho, H. J., Zhang, J., Pavlenco, A., Liu, S., Sidhu, S., Huang, J-S. & Moe, O. W., Sep 2013, In : Kidney international. 84, 3, p. 468-481 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Using functional signature ontology (FUSION) to identify mechanisms of action for Natural products

Potts, M. B., Kim, H. S., Fisher, K. W., Hu, Y., Carrasco, Y. P., Bulut, G. B., Ou, Y. H., Herrera-Herrera, M. L., Cubillos, F., Mendiratta, S., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Huang, L. J. S., Lewis, R. E., MacMillan, J. B. & White, M. A., Oct 15 2013, In : Science Signaling. 6, 297, ra90.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Erythroblastic sarcoma presenting as bilateral ovarian masses in an infant with pure erythroid leukemia

Wang, H. Y., Huang, L. J. S., Liu, Z., Garcia, R., Li, S. & Galliani, C. A., May 1 2011, In : Human Pathology. 42, 5, p. 749-758 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor

Bulut, G. B., Sulahian, R., Ma, Y., Chi, N. W. & Huang, L. J. S., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6449-6457 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Advances in understanding the pathogenesis of primary familial and congenital polycythaemia

Huang, L. J., Shen, Y. M. & Bulut, G. B., Mar 2010, In : British Journal of Haematology. 148, 6, p. 844-852 9 p.

Research output: Contribution to journalReview article

25 Scopus citations

A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F)

Zhao, L., Ma, Y., Seemann, J. & Huang, L. J. S., Feb 15 2010, In : Biochemical Journal. 426, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Chemical and biological studies of nakiterpiosin and nakiterpiosinone

Gao, S., Wang, Q., Huang, L. J. S., Lum, L. & Chen, C., Jan 13 2010, In : Journal of the American Chemical Society. 132, 1, p. 371-383 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ

Patrick, D. M., Zhang, C., Tao, Y., Yao, H., Qi, X., Schwartz, R. J., Huang, J-S. & Olson, E. N., Aug 1 2010, In : Genes and Development. 24, 15, p. 1614-1619 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Tirado, C. A., Chen, W., Huang, L. J. S., Laborde, C., Hiemenz, M. C., Valdez, F., Ho, K., Winick, N., Lou, Z. & Koduru, P., Dec 1 2010, In : Leukemia Research. 34, 12, p. 1674-1676 3 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

A JAK2 interdomain linker relays epo receptor engagement signals to kinase activation

Zhao, L., Dong, H., Zhang, C., Kinch, L., Osawa, M., Iacovino, M., Grishin, N. V., Kyba, M. & Huang, J-S., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26988-26991 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
39 Scopus citations
2008

Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F

Lu, X., Huang, L. J. S. & Lodish, H. F., Feb 29 2008, In : Journal of Biological Chemistry. 283, 9, p. 5258-5266 9 p.

Research output: Contribution to journalArticle

88 Scopus citations
2007

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

Michaely, P., Zhao, Z., Li, W. P., Garuti, R., Huang, L. J., Hobbs, H. H. & Cohen, J. C., Jul 25 2007, In : EMBO Journal. 26, 14, p. 3273-3282 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms

Tong, W., Sulahian, R., Gross, A. W., Hendon, N., Lodish, H. F. & Huang, L. J. S., Dec 15 2006, In : Journal of Biological Chemistry. 281, 50, p. 38930-38940 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2003

Development of human protein reference database as an initial platform for approaching systems biology in humans

Peri, S., Navarro, J. D., Amanchy, R., Kristiansen, T. Z., Jonnalagadda, C. K., Surendranath, V., Niranjan, V., Muthusamy, B., Gandhi, T. K. B., Gronborg, M., Ibarrola, N., Deshpande, N., Shanker, K., Shivashankar, H. N., Rashmi, B. P., Ramya, M. A., Zhao, Z., Chandrika, K. N., Padma, N., Harsha, H. C. & 32 others, Yatish, A. J., Kavitha, M. P., Menezes, M., Choudhury, D. R., Suresh, S., Ghosh, N., Saravana, R., Chandran, S., Krishna, S., Joy, M., Anand, S. K., Madavan, V., Joseph, A., Wong, G. W., Schiemann, W. P., Constantinescu, S. N., Huang, L., Khosravi-Far, R., Steen, H., Tewari, M., Ghaffari, S., Blobe, G. C., Dang, C. V., Garcia, J. G. N., Pevsner, J., Jensen, O. N., Roepstorff, P., Deshpande, K. S., Chinnaiyan, A. M., Hamosh, A., Chakravarti, A. & Pandey, A., Oct 1 2003, In : Genome Research. 13, 10, p. 2363-2371 9 p.

Research output: Contribution to journalArticle

768 Scopus citations
2002

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation

Flint-Ashtamker, G., Eisen-Lev, R., Cohen, J., Jun-shen Huang, L. & Neumann, D., May 8 2002, In : FEBS Letters. 518, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2001

Functional Cloning of the Proto-oncogene Brain Factor-1 (BF-1) As a Smad-binding Antagonist of Transforming Growth Factor-β Signaling

Rodriguez, C., Huang, L. J. S., Son, J. K., McKee, A., Xiao, Z. & Lodish, H. F., Aug 10 2001, In : Journal of Biological Chemistry. 276, 32, p. 30224-30230 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

PKA, PKC, and AKAP localization in and around the neuromuscular junction

Perkins, G. A., Wang, L., Huang, L. J. S., Humphries, K., Yao, V. J., Martone, M., Deerinck, T. J., Barraclough, D. M., Violin, J. D., Smith, D., Newton, A., Scott, J. D., Taylor, S. S. & Ellisman, M. H., Oct 23 2001, In : BMC Neuroscience. 2, 17.

Research output: Contribution to journalArticle

43 Scopus citations

The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

Constantinescu, S. N., Huang, L. J. S., Nam, H. S. & Lodish, H. F., Jan 1 2001, In : Molecular cell. 7, 2, p. 377-385 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

The N-terminal domain of Janus kinase 2 is required for golgi processing and cell surface expression of erythropoietin receptor

Huang, L. J. S., Constantinescu, S. N. & Lodish, H. F., Jan 1 2001, In : Molecular cell. 8, 6, p. 1327-1338 12 p.

Research output: Contribution to journalArticle

224 Scopus citations
1999

NH2-terminal targeting motifs direct dual specificity A-kinase- anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum

Huang, L. J. S., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T. J., Ellisman, M. H. & Taylor, S. S., May 31 1999, In : Journal of Cell Biology. 145, 5, p. 951-959 9 p.

Research output: Contribution to journalArticle

132 Scopus citations

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L. J. S., Taylor, S. S., Scott, J. D. & Korsmeyer, S. J., Apr 1999, In : Molecular cell. 3, 4, p. 413-422 10 p.

Research output: Contribution to journalArticle

524 Scopus citations
1998

Camp-dependent protein kinase: Structural basis for subcellular localization

Taylor, S. S., Naravana, N., Huang, L., Banky, P., Wang, L., Hauer, J., Ma, F. & Cheng, X., Dec 1 1998, In : FASEB Journal. 12, 8, p. A1323

Research output: Contribution to journalArticle

51 Scopus citations
59 Scopus citations
1997

Camp-dependent protein kinase: Structural basis for activation and subcellular localization

Tavlor, S. S., Naravana, N., Lew, J., Cheng, X., Wen, W., Aimes, R., Gibson, R. M. & Huang, L. J., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1294

Research output: Contribution to journalArticle

D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain

Huang, L. J. S., Durick, K., Weiner, J. A., Chun, J. & Taylor, S. S., Oct 14 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 21, p. 11184-11189 6 p.

Research output: Contribution to journalArticle

191 Scopus citations

Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits

Huang, L. J. S., Durick, K., Weiner, J. A., Chun, J. & Taylor, S. S., Apr 8 1997, In : Journal of Biological Chemistry. 272, 12, p. 8057-8064 8 p.

Research output: Contribution to journalArticle

237 Scopus citations

Structural studies of the dimerization/docking domain of the type la regulatory subunit of PKA

Banky, P., Huang, J. L. & Taylor, S. S., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1045

Research output: Contribution to journalArticle

The splice variants of D-AKAP1 differ in subcellular localization and tissue-specific expression

Huang, L. J. S., Durick, K. & Taylor, S. S., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1064

Research output: Contribution to journalArticle