Cell Biology - Live Cell Imaging Core Facility

Research Output

2019

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

Huang, L., Chambliss, K. L., Gao, X., Yuhanna, I. S., Behling-Kelly, E., Bergaya, S., Ahmed, M., Michaely, P., Luby-Phelps, K., Darehshouri, A., Xu, L., Fisher, E. A., Ge, W. P., Mineo, C. & Shaul, P. W., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

17 Scopus citations
2018

Distinct reorganization of collagen architecture in lipopolysaccharide-mediated premature cervical remodeling

Nallasamy, S., Akins, M., Tetreault, B., Luby-Phelps, K. & Mahendroo, M., Jan 1 2018, In : Biology of Reproduction. 98, 1, p. 63-74 12 p., iox155.

Research output: Contribution to journalArticle

5 Scopus citations

Quantitative analyses of SHG endomicroscopy images of cervical collagen network for detecting preterm birth in mouse models

Liang, W., Sakulsaengprapha, V., Luby-Phelps, K., Mahendroo, M. & Li, X., Jan 1 2018, Clinical and Translational Biophotonics, TRANSLATIONAL 2018. OSA - The Optical Society, Vol. Part F91-TRANSLATIONAL 2018.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

Afadin orients cell division to position the tubule lumen in developing renal tubules

Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M., Luby-Phelps, K. & Marciano, D. K., Oct 1 2017, In : Development (Cambridge). 144, 19, p. 3511-3520 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Dalton, G., An, S. W., Al-Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby-Phelps, K., Kohler, J. J., Birnbaumer, L. & Huang, C. L., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. 752-757 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

Caielli, S., Athale, S., Domic, B., Murat, E., Chandra, M., Banchereau, R., Baisch, J., Phelps, K., Clayton, S., Gong, M., Wright, T., Punaro, M., Palucka, K., Guiducci, C., Banchereau, J. & Pascual, V., 2016, In : Journal of Experimental Medicine. 213, 5, p. 697-713 17 p.

Research output: Contribution to journalArticle

132 Scopus citations
2015

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

Acar, M., Kocherlakota, K. S., Murphy, M. M., Peyer, J. G., Oguro, H., Inra, C. N., Jaiyeola, C., Zhao, Z., Luby-Phelps, K. & Morrison, S. J., Oct 1 2015, In : Nature. 526, 7571, p. 126-130 5 p.

Research output: Contribution to journalArticle

252 Scopus citations
2014

Autophagy is essential for cardiac morphogenesis during vertebrate development

Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R. J., Cleaver, O., Levine, B. & Amatruda, J. F., Apr 2014, In : Autophagy. 10, 4, p. 572-587 16 p.

Research output: Contribution to journalArticle

60 Scopus citations

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

Sun, K., Kusminski, C. M., Luby-Phelps, K., Spurgin, S. B., An, Y. A., Wang, Q. A., Holland, W. L. & Scherer, P. E., Jul 2014, In : Molecular Metabolism. 3, 4, p. 474-483 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Asaithamby, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., May 22 2014, In : Cell. 157, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., Apr 24 2014, In : Cell. 157, 3, p. 565-579 15 p.

Research output: Contribution to journalArticle

269 Scopus citations
2013

Fiber-optic multiphoton endomicroscopy

Liang, W., Hall, G., Zhang, Y., Akins, M. L., Xi, J., Li, M. J., Luby-Phelps, K., Mahendroo, M., Bhujwalla, Z., Glunde, K. & Li, X., Jan 1 2013, Frontiers in Optics, FIO 2013. Optical Society of America, (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Quantitative fluorescence co-localization to study protein-receptor complexes

Pompey, S. N., Michaely, P. & Luby-Phelps, K., 2013, In : Methods in molecular biology (Clifton, N.J.). 1008, p. 439-453 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Quantitative fl uorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake

Pompey, S., Zhao, Z., Luby-Phelps, K. & Michaely, P., Mar 1 2013, In : Journal of lipid research. 54, 3, p. 744-753 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

The physical chemistry of cytoplasm and its influence on cell function: An update

Luby-Phelps, K., Sep 1 2013, In : Molecular biology of the cell. 24, 17, p. 2593-2596 4 p.

Research output: Contribution to journalReview article

67 Scopus citations
2012

A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy

Zhang, Y., Akins, M. L., Murari, K., Xi, J., Li, M. J., Luby-Phelps, K., Mahendroo, M. & Li, X., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 12878-12883 6 p.

Research output: Contribution to journalArticle

95 Scopus citations

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content

Mundy, D. I., Li, W. P., Luby-Phelps, K. & Anderson, R. G. W., Mar 1 2012, In : Molecular biology of the cell. 23, 5, p. 864-880 17 p.

Research output: Contribution to journalArticle

42 Scopus citations

Fiber-optic second harmonic generation endomicroscopy: A potential tool for diagnosis of preterm birth

Zhang, Y., Akins, M. L., Murari, K., Li, M. J., Luby-Phelps, K., Mahendroo, M. & Li, X., Dec 1 2012, Biomedical Optics, BIOMED 2012. p. BSu3A.35 (Biomedical Optics, BIOMED 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Interactions with WNK (With No Lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

Sengupta, S., Tu, S. W., Wedin, K., Earnest, S., Stippec, S., Luby-Phelps, K. & Cobb, M. H., Nov 2 2012, In : Journal of Biological Chemistry. 287, 45, p. 37868-37879 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Nonlinear optical fiber endomicroscopy towards clinical applications

Zhang, Y., Liang, W., Akins, M. L., Li, M. J., Luby-Phelps, K., Mahendroo, M. & Li, X., Dec 1 2012, 2012 IEEE Photonics Conference, IPC 2012. p. 937-938 2 p. 6359304. (2012 IEEE Photonics Conference, IPC 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2011

Cervical softening during pregnancy: Regulated changes in collagen cross-linking and composition of matricellular proteins in the mouse

Akins, M. L., Luby-Phelps, K., Bank, R. A. & Mahendroo, M., May 1 2011, In : Biology of reproduction. 84, 5, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Fiber-optic two-photon fluorescence and second harmonic generation endomicroscopy

Zhang, Y., Murari, K., Xi, J., Chen, Y., Arkin, M., Kakkad, S., Mahendroo, M., Luby-Phelps, K., Li, S. P., Bhujwalla, Z., Glunde, K., Li, M. J. & Li, X., Dec 1 2011, CLEO: Science and Innovations, CLEO_SI 2011. (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fiber-optic two-photon fluorescence and second harmonic generation endomicroscopy

Zhang, Y., Murari, K., Xi, J., Chen, Y., Arkin, M., Kakkad, S., Mahendroo, M., Luby-Phelps, K., Li, S. P., Bhujwalla, Z., Glunde, K., Li, M. J. & Li, X., Sep 1 2011, 2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011. 5950838. (2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Fiber-optic two-photon fluorescence and second harmonic generation endomicroscopy

Zhang, Y., Murari, K., Xi, J., Chen, Y., Arkin, M., Kakkad, S., Mahendroo, M., Luby-Phelps, K., Li, S. P., Bhujwalla, Z., Glunde, K., Li, M. J. & Li, X., Dec 1 2011, Quantum Electronics and Laser Science Conference, QELS 2011. (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fiber-optic two-photon fluorescence and second harmonic generation endomicroscopy

Zhang, Y., Murari, K., Xi, J., Chen, Y., Arkin, M., Kakkad, S., Mahendroo, M., Luby-Phelps, K., Li, S. P., Bhujwalla, Z., Glunde, K., Li, M. J. & Li, X., Dec 1 2011, CLEO: Applications and Technology, CLEO_AT 2011. (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Image-based genome-wide siRNA screen identifies selective autophagy factors

Orvedahl, A., Sumpter, R., Xiao, G., Ng, A., Zou, Z., Tang, Y., Narimatsu, M., Gilpin, C., Sun, Q., Roth, M., Forst, C. V., Wrana, J. L., Zhang, Y. E., Luby-Phelps, K., Xavier, R. J., Xie, Y. & Levine, B., Dec 1 2011, In : Nature. 480, 7375, p. 113-117 5 p.

Research output: Contribution to journalArticle

286 Scopus citations

Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles

Sathe, M. N., Woo, K., Kresge, C., Bugde, A., Luby-Phelps, K., Lewis, M. A. & Feranchak, A. P., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 25363-25376 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Subcellular particles tracking in time-lapse confocal microscopy images

Li, S., Luby-Phelps, K., Zhang, B., Wu, X. & Gao, J., 2011, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. p. 5973-5976 4 p. 6091476

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
314 Scopus citations

WNK1 is required for mitosis and abscission

Tu, S. W., Bugde, A., Luby-Phelps, K. & Cobb, M. H., Jan 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 4, p. 1385-1390 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2010

Distinguishing different stages of mouse pregnancy using second harmonic generation images

Yousefi, S., Kehtarnavaz, N., Akins, M., Luby-Phelps, K. & Mahendroo, M., May 24 2010, 2010 42nd Southeastern Symposium on System Theory, SSST 2010. p. 44-46 3 p. 5442801. (Proceedings of the Annual Southeastern Symposium on System Theory).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Distinguishing second harmonic generation images of mouse preterm labor via wavelet-based texture features

Sobhi-Afshar, A., Kehtarnavaz, N., Akins, M., Luby-Phelps, K. & Mahendroo, M., Nov 8 2010, 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2010 - Proceedings. p. 674-677 4 p. 5495114. (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Epicardial Spindle Orientation Controls Cell Entry into the Myocardium

Wu, M., Smith, C. L., Hall, J. A., Lee, I., Luby-Phelps, K. & Tallquist, M. D., Jul 1 2010, In : Developmental cell. 19, 1, p. 114-125 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium

Feranchak, A. P., Lewis, M. A., Kresge, C., Sathe, M., Bugde, A., Luby-Phelps, K., Antich, P. P. & Fitz, J. G., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 8138-8147 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
69 Scopus citations

Separation of preterm infection model from normal pregnancy in mice using texture analysis of Second Harmonic Generation images

Yousefi, S., Kehtarnavaz, N., Akins, M., Luby-Phelps, K. & Mahendroo, M., Dec 1 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. p. 5314-5317 4 p. 5626349. (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Sterol-induced dislocation of 3-Hydroxy-3-methylglutaryl coenzyme a reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets

Hartman, I. Z., Liu, P., Zehmer, J. K., Luby-Phelps, K., Jo, Y., Anderson, R. G. W. & DeBose-Boyd, R. A., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19288-19298 11 p.

Research output: Contribution to journalArticle

65 Scopus citations
2009

Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia.

Insinna, C., Luby-Phelps, K., Link, B. A. & Besharse, J. C., 2009, In : Methods in cell biology. 93, p. 219-234 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells

Wu, Z., Luby-Phelps, K., Bugde, A., Molyneux, L. A., Denard, B., Li, W. H., Süel, G. M. & Garbers, D. L., Nov 16 2009, In : Journal of Cell Biology. 187, 4, p. 513-524 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Dynamic Near-Infrared Optical Imaging of 2-Deoxyglucose Uptake by Intracranial Glioma of Athymic Mice

Zhou, H., Luby-Phelps, K., Mickey, B. E., Habib, A. A., Mason, R. P. & Zhao, D., Dec 1 2009, In : PloS one. 4, 11, e0008051.

Research output: Contribution to journalArticle

51 Scopus citations

SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function

McMahon, K. A., Zajicek, H., Li, W. P., Peyton, M. J., Minna, J. D., Hernandez, V. J., Luby-Phelps, K. & Anderson, R. G. W., Apr 22 2009, In : EMBO Journal. 28, 8, p. 1001-1015 15 p.

Research output: Contribution to journalArticle

134 Scopus citations

Systemic fate of the adipocyte-derived factor adiponectin

Halberg, N., Schraw, T. D., Wang, Z. V., Kim, J. Y., Yi, J., Hamilton, M. P., Luby-Phelps, K. & Scherer, P. E., Sep 1 2009, In : Diabetes. 58, 9, p. 1961-1970 10 p.

Research output: Contribution to journalArticle

123 Scopus citations

Tracking multiple interacting subcellular structure by sequential Monte Carlo method

Wen, Q., Luby-Phelps, K. & Gao, J., Aug 26 2009, In : International Journal of Data Mining and Bioinformatics. 3, 3, p. 314-332 19 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

A statistical approach for intensity loss compensation of confocal microscopy images

Gopinath, S., Wen, Q., Thakoor, N., Luby-Phelps, K. & Gao, J. X., Apr 1 2008, In : Journal of Microscopy. 230, 1, p. 143-159 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors

Luby-Phelps, K., Fogerty, J., Baker, S. A., Pazour, G. J. & Besharse, J. C., Feb 1 2008, In : Vision Research. 48, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2007

Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development

Qu, X., Zou, Z., Sun, Q., Luby-Phelps, K., Cheng, P., Hogan, R. N., Gilpin, C. & Levine, B., Mar 9 2007, In : Cell. 128, 5, p. 931-946 16 p.

Research output: Contribution to journalArticle

463 Scopus citations

Mitochondria mass is low in mouse substantia nigra dopamine neurons: Implications for Parkinson's disease

Liang, C. L., Wang, T. T., Luby-Phelps, K. & German, D. C., Feb 1 2007, In : Experimental Neurology. 203, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

125 Scopus citations