Hamon Center Therapeutic Oncology - Minna Lab

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2006

Multiple oncogenic changes (K-RASV12, p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells

Sato, M., Vaughan, M. B., Girard, L., Peyton, M., Lee, W., Shames, D. S., Ramirez, R. D., Sunaga, N., Gazdar, A. F., Shay, J. W. & Minna, J. D., Feb 15 2006, In : Cancer Research. 66, 4, p. 2116-2128 13 p.

Research output: Contribution to journalArticle

195 Scopus citations

Non-small cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation

Das, A. K., Sato, M., Story, M. D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A. F., Shay, J. W., Minna, J. D. & Nirodi, C. S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9601-9608 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines

Witta, S. E., Gemmill, R. M., Hirsch, F. R., Coldren, C. D., Hedman, K., Ravdel, L., Helfrich, B., Dziadziuszko, R., Chan, D. C., Sugita, M., Chan, Z., Baron, A., Franklin, W., Drabkin, H. A., Girard, L., Gazdar, A. F., Minna, J. D. & Bunn, P. A., Jan 15 2006, In : Cancer Research. 66, 2, p. 944-950 7 p.

Research output: Contribution to journalArticle

391 Scopus citations

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

Zhou, B. B. S., Peyton, M., He, B., Liu, C., Girard, L., Caudler, E., Lo, Y., Baribaud, F., Mikami, I., Reguart, N., Yang, G., Li, Y., Yao, W., Vaddi, K., Gazdar, A. F., Friedman, S. M., Jablons, D. M., Newton, R. C., Fridman, J. S., Minna, J. D. & 1 others, Scherle, P. A., Jul 2006, In : Cancer Cell. 10, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

289 Scopus citations

The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells

Ueda, K., Kawashima, H., Ohtani, S., Deng, W. G., Ravoori, M., Bankson, J., Gao, B., Girard, L., Minna, J. D., Roth, J. A., Kundra, V. & Ji, L., Oct 1 2006, In : Cancer Research. 66, 19, p. 9682-9690 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
2005

Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer

Amann, J., Kalyankrishna, S., Massion, P. P., Ohm, J. E., Girard, L., Shigematsu, H., Peyton, M., Juroske, D., Huang, Y., Salmon, J. S., Kim, Y. H., Pollack, J. R., Yanagisawa, K., Gazdar, A., Minna, J. D., Kurie, J. M. & Carbone, D. P., Jan 1 2005, In : Cancer Research. 65, 1, p. 226-235 10 p.

Research output: Contribution to journalArticle

358 Scopus citations

Erratum: Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays (Nucleic Acids Research (2005) vol. 33 (409-421))

Yap, Y. L., Lam, D. C. L., Girard, L., Zhang, X. W., Hernandez, D., Gras, R., Wang, E., Chiu, S. W., Chung, L. P., Lam, W. K., Smith, D. K., Minna, J. D., Danchin, A. & Wong, M. P., 2005, In : Nucleic Acids Research. 33, 8, p. 2764 1 p.

Research output: Contribution to journalArticle

Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells

Henderson, L. J., Coe, B. P., Lee, E. H. L., Girard, L., Gazdar, A. F., Minna, J. D., Lam, S., MacAulay, C. & Lam, W. L., Apr 25 2005, In : British Journal of Cancer. 92, 8, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

High resolution SNP arrays identify amplified regions in lung cancer

Weir, B., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J., Janne, P., Li, C., Sellers, W., Naoki, K., Richards, W., Sugarbaker, D., Chen, F., Rubin, M., Girard, L., Minna, J. & Christiani, D., Aug 2005, In : Cancer Biology and Therapy. 4, 8

Research output: Contribution to journalArticle

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

Zhao, X., Weir, B. A., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., Sugarbaker, D., Chen, F., Rubin, M. A., Jänne, P. A., Girard, L., Minna, J., Christiani, D., Li, C., Sellers, W. R. & Meyerson, M., Jul 1 2005, In : Cancer Research. 65, 13, p. 5561-5570 10 p.

Research output: Contribution to journalArticle

275 Scopus citations

Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas

Koh, K. H., Kang, H. J., Li, L. S., Kim, N. G., You, K. T., Yang, E., Kim, H., Kim, H. J., Yun, C. O., Kim, K. S. & Kim, H., 2005, In : Laboratory Investigation. 85, 9, p. 1130-1138 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer

Holloway, S. E., Beck, A. W., Girard, L., Jaber, M. R., Barnett, C. C., Brekken, R. A. & Fleming, J. B., Mar 2005, In : Journal of the American College of Surgeons. 200, 3, p. 371-377 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays

Dobbin, K. K., Beer, D. G., Meyerson, M., Yeatman, T. J., Gerald, W. L., Jacobson, J. W., Conley, B., Buetow, K. H., Heiskanen, M., Simon, R. M., Minna, J. D., Girard, L., Misek, D. E., Taylor, J. M. G., Hanash, S., Naoki, K., Hayes, D. N., Ladd-Acosta, C., Enkemann, S. A., Viale, A. & 1 others, Giordano, T. J., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 565-572 8 p.

Research output: Contribution to journalArticle

134 Scopus citations
2004

Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

Bentires-Alj, M., Paez, J. G., David, F. S., Keilhack, H., Halmos, B., Naoki, K., Maris, J. M., Richardson, A., Bardelli, A., Sagarbaker, D. J., Richards, W. G., Du, J., Girard, L., Minna, J. D., Loh, M. L., Fisher, D. E., Velculescu, V. E., Vogelstein, B., Meyerson, M., Sellers, W. R. & 1 others, Neel, B. G., Dec 15 2004, In : Cancer Research. 64, 24, p. 8816-8820 5 p.

Research output: Contribution to journalArticle

339 Scopus citations

An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

Zhao, X., Li, C., Paez, J. G., Chin, K., Jänne, P. A., Chen, T. H., Girard, L., Minna, J., Christiani, D., Leo, C., Gray, J. W., Sellers, W. R. & Meyerson, M., May 1 2004, In : Cancer Research. 64, 9, p. 3060-3071 12 p.

Research output: Contribution to journalArticle

432 Scopus citations

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene

Ivanov, S. V., Ward, J. M., Tessarollo, L., McAreavey, D., Sachdev, V., Fananapazir, L., Banks, M. K., Morris, N., Djurickovic, D., Devor-Henneman, D. E., Wei, M. H., Alvord, G. W., Gao, B., Richardson, J. A., Minna, J. D., Rogawski, M. A. & Lerman, M. I., Sep 2004, In : American Journal of Pathology. 165, 3, p. 1007-1018 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas

Kim, H., Suk, W. N., Rhee, H., Long, S. L., Hyun, J. K., Kwi, H. K., Nam, K. K., Song, J., Liu, E. T. B. & Kim, H., Aug 19 2004, In : Oncogene. 23, 37, p. 6218-6225 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines

Jänne, P. A., Li, C., Zhao, X., Girard, L., Chen, T. H., Minna, J., Christiani, D. C., Johnson, B. E. & Meyerson, M., Apr 8 2004, In : Oncogene. 23, 15, p. 2716-2726 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

Ramirez, R. D., Sheridan, S., Girard, L., Sato, M., Kim, Y., Pollack, J., Peyton, M., Zou, Y., Kurie, J. M., DiMaio, J. M., Milchgrub, S., Smith, A. L., Souza, R. F., Gilbey, L., Zhang, X., Gandia, K., Vaughan, M. B., Wright, W. E., Gazdar, A. F., Shay, J. W. & 1 others, Minna, J. D., Dec 15 2004, In : Cancer Research. 64, 24, p. 9027-9034 8 p.

Research output: Contribution to journalArticle

412 Scopus citations

Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma

Long, S. L., Kim, H., Rhee, H., Se, H. K., Dong, H. S., Kyung, Y. C., Park, K. S., Paik, Y. K., Chang, J. & Kim, H., Nov 2004, In : Proteomics. 4, 11, p. 3394-3400 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

Li, Q. L., Kim, H. R., Kim, W. J., Choi, J. K., Hee Lee, Y., Kim, H. M., Shan Li, L., Kim, H., Chang, J., Ito, Y., Youl Lee, K. & Bae, S. C., Jan 30 2004, In : Biochemical and Biophysical Research Communications. 314, 1, p. 223-228 6 p.

Research output: Contribution to journalArticle

111 Scopus citations
2003

CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity

Carboni, G. L., Gao, B., Nishizaki, M., Xu, K., Minna, J. D., Roth, J. A. & Ji, L., Jan 30 2003, In : Oncogene. 22, 4, p. 615-626 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Chromosomal imbalances in the colorectal carcinomas with microsatellite instability

Li, L. S., Kim, N. G., Kim, S. H., Park, C., Kim, H., Kang, H. J., Koh, K. H., Kim, S. N., Kim, W. H., Kim, N. K. & Kim, H., Oct 1 2003, In : American Journal of Pathology. 163, 4, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Clinicopathologic characteristics related to the high variability of coding mononucleotide repeat sequences in tumors with high-microsatellite instability

Chung, K. Y., Kim, N. G., Li, L. S., Kim, H., Kim, H., Nam, C. M., Kim, H. & Shin, D. H., Mar 2003, In : Oncology Reports. 10, 2, p. 439-444 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of novel gene expression targets for the ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma

Agathanggelou, A., Bièche, I., Ahmed-Choudhury, J., Nicke, B., Dammann, R., Baksh, S., Gao, B., Minna, J. D., Downward, J., Maher, E. R. & Latif, F., Sep 1 2003, In : Cancer Research. 63, 17, p. 5344-5351 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer

Sato, M., Girard, L., Sekine, I., Sunaga, N., Ramirez, R. D., Kamibayashi, C. & Minna, J. D., Oct 16 2003, In : Oncogene. 22, 46, p. 7243-7246 4 p.

Research output: Contribution to journalArticle

46 Scopus citations
2002

Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations

Jiang, X., Hanna, Z., Kaouass, M., Girard, L. & Jolicoeur, P., Sep 1 2002, In : Journal of virology. 76, 18, p. 9046-9059 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo

Ji, L., Nishizaki, M., Gao, B., Burbee, D., Kondo, M., Kamibayashi, C., Xu, K., Yen, N., Atkinson, E. N., Fang, B., Lerman, M. I., Roth, J. A. & Minna, J. D., May 1 2002, In : Cancer Research. 62, 9, p. 2715-2720 6 p.

Research output: Contribution to journalArticle

160 Scopus citations

Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability

Kim, N. G., Rhee, H., Li, L. S., Kim, H., Lee, J. S., Kim, J. H., Nam, K. K. & Kim, H., Aug 1 2002, In : Oncogene. 21, 33, p. 5081-5087 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women

Rathi, A., Virmani, A. K., Schorge, J. O., Elias, K. J., Maruyama, R., Minna, J. D., Mok, S. C., Girard, L., Fishman, D. A. & Gazdar, A. F., Nov 1 2002, In : Clinical Cancer Research. 8, 11, p. 3324-3331 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays

Balog, R. P., De Souza, Y. E. P., Tang, H. M., DeMasellis, G. M., Gao, B., Avila, A., Gaban, D. J., Mittelman, D., Minna, J. D., Luebke, K. J. & Garner, H. R., Oct 15 2002, In : Analytical Biochemistry. 309, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

DNA methylation profiles of lung tumors

Toyooka, S., Toyooka, K. O., Maruyama, R., Virmani, A. K., Girard, L., Miyajima, K., Harada, K., Ariyoshi, Y., Takahashi, T., Sugio, K., Brambilla, E., Gilcrease, M., Minna, J. D. & Gazdar, A. F., Nov 2001, In : Molecular Cancer Therapeutics. 1, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

220 Scopus citations

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

Burbee, D. G., Forgacs, E., Zöchbauer-Müller, S., Shivakumar, L., Fong, K., Gao, B., Randle, D., Kondo, M., Virmani, A., Bader, S., Sekido, Y., Latif, F., Milchgrub, S., Toyooka, S., Gazdar, A. F., Lerman, M. I., Zabarovsky, E., White, M. & Minna, J. D., May 2 2001, In : Journal of the National Cancer Institute. 93, 9, p. 691-699 9 p.

Research output: Contribution to journalArticle

688 Scopus citations

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

Tomizawa, Y., Sekido, Y., Kondo, M., Gao, B., Yokota, J., Roche, J., Drabkin, H., Lerman, M. I., Gazdar, A. F. & Minna, J. D., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 13954-13959 6 p.

Research output: Contribution to journalArticle

187 Scopus citations
2000

Functional properties of a new voltage-dependent calcium channel auxiliary subunit gene (CACNA2D2)

Gao, B., Sekido, Y., Maximov, A., Saad, M., Forgacs, E., Latif, F., Wei, M. H., Lerman, M., Lee, J. H., Perez-Reyes, E., Bezprozvanny, I. & Minna, J. D., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 12237-12242 6 p.

Research output: Contribution to journalArticle

140 Scopus citations

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering

Girard, L., Zochbauer-Muller, S., Virmani, A. K., Gazdar, A. F. & Minna, J. D., Sep 1 2000, In : Cancer Research. 60, 17, p. 4894-4906 13 p.

Research output: Contribution to journalArticle

302 Scopus citations

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints

Wistuba, I. I., Behrens, C., Virmani, A. K., Mele, G., Milchgrub, S., Girard, L., Fondon, J. W., Garner, H. R., McKay, B., Latif, F., Lerman, M. I., Lam, S., Gazdar, A. F. & Minna, J. D., Apr 1 2000, In : Cancer Research. 60, 7, p. 1949-1960 12 p.

Research output: Contribution to journalArticle

376 Scopus citations
499 Scopus citations

Two distinct Notch1 mutant alleles are involved in the induction of T- cell leukemia in c-myc transgenic mice

Hoemann, C. D., Beaulieu, N., Girard, L., Rebai, N. & Jolicoeur, P., Jun 2000, In : Molecular and Cellular Biology. 20, 11, p. 3831-3842 12 p.

Research output: Contribution to journalArticle

74 Scopus citations
1999

In situ observation of apoptosis and proliferation in breast cancer and its precancerous lesions

Sun, S., Li, L. & Sun, D., Nov 1999, In : Zhonghua zhong liu za zhi [Chinese journal of oncology]. 21, 6, p. 447-449 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
1998
13 Scopus citations

A simple and rapid method for purifying the extracellular domain of human tissue factor

Gao, B., Li, S. & Thorpe, P. E., Sep 1998, In : Thrombosis Research. 91, 5, p. 249-253 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature

Ran, S., Gao, B., Duffy, S., Watkins, L., Rote, N. & Thorpe, P. E., Oct 15 1998, In : Cancer Research. 58, 20, p. 4646-4653 8 p.

Research output: Contribution to journalArticle

117 Scopus citations
1996

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTV(D)/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

Girard, L., Hanna, Z., Beaulieu, N., Hoemann, C. D., Simard, C., Kozak, C. A. & Jolicoeur, P., 1996, In : Genes and Development. 10, 15, p. 1930-1944 15 p.

Research output: Contribution to journalArticle

190 Scopus citations
1991

Cloning and expression of a widely distributed (type IV) adenylyl cyclase

Gao, B. & Gilman, A. G., 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 22, p. 10178-10182 5 p.

Research output: Contribution to journalArticle

268 Scopus citations
1987

A second form of the beta subunit of signal-transducing G proteins.

Gao, B., Gilman, A. G. & Robishaw, J. D., Sep 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 17, p. 6122-6125 4 p.

Research output: Contribution to journalArticle

77 Scopus citations

The G protein β2 complementary DNA encodes the β35 subunit

Gao, B., Mumby, S. & Gilman, A. G., 1987, In : Journal of Biological Chemistry. 262, 36, p. 17254-17257 4 p.

Research output: Contribution to journalArticle

29 Scopus citations
1986

Sequence of mRNA coding for bindin, a species-specific sea urchin sperm protein required for fertilization

Gao, B., Klein, L. E., Britten, R. J. & Davidson, E. H., 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 22, p. 8634-8638 5 p.

Research output: Contribution to journalArticle

56 Scopus citations