Research Output 2002 2017

2017
3 Citations (Scopus)

Identification of 5-methoxy-2-(diformylmethylidene)-3,3-dimethylindole as an anti-influenza a virus agent

Tan, M. C., Wong, W. Y., Ng, W. L., Yeo, K. S., Begam, T., Mohidin, M., Lim, Y. Y., Lafta, F., Ali, H. M. & Ea, C. K., Jan 1 2017, In : PLoS One. 12, 1, e0170352.

Research output: Contribution to journalArticle

Orthomyxoviridae
Viruses
Antiviral Agents
Chemical activation
Derivatives
3 Citations (Scopus)

JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain

Yeo, K. S., Tan, M. C., Lim, Y. Y. & Ea, C. K., Dec 1 2017, In : Scientific Reports. 7, 1, 15407.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Protein Folding
Proteins
Computational Biology
Fluorescence Microscopy
4 Citations (Scopus)

Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway

Ng, W. L., Marinov, G. K., Chin, Y. M., Lim, Y. Y. & Ea, C. K., Dec 1 2017, In : Scientific Reports. 7, 1, 12227.

Research output: Contribution to journalArticle

Macrophage Activation
Untranslated RNA
Genes
Cell Cycle
Infection
2016
37 Citations (Scopus)

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

Ng, W. L., Marinov, G. K., Liau, E. S., Lam, Y. L., Lim, Y. Y. & Ea, C. K., Sep 1 2016, In : RNA Biology. 13, 9, p. 861-871 11 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
RNA
Exons
Cytoplasm
Equipment and Supplies
6 Citations (Scopus)

JMJD8 is a positive regulator of TNF-induced NF-κB signaling

Yeo, K. S., Tan, M. C., Wong, W. Y., Loh, S. W., Lam, Y. L., Tan, C. L., Lim, Y. Y. & Ea, C. K., Sep 27 2016, In : Scientific Reports. 6, 34125.

Research output: Contribution to journalArticle

Histone Demethylases
Apoptosis
Protein Deficiency
Ubiquitination
RNA Interference
2015
1 Citation (Scopus)

A cell-based screening system for anti-influenza A virus agents

Wong, W. Y., Loh, S. W., Ng, W. L., Tan, M. C., Yeo, K. S., Looi, C. Y., Maah, M. J. & Ea, C. K., Jan 1 2015, In : Scientific Reports. 5, 8672.

Research output: Contribution to journalArticle

Influenza A virus
Virus Diseases
Virus Replication
Thiosemicarbazones
Interferon Type I
2014
5 Citations (Scopus)

Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment

Loh, S. W., Ng, W. L., Yeo, K. S., Lim, Y. Y. & Ea, C. K., Jul 31 2014, In : PLoS One. 9, 7, e103915.

Research output: Contribution to journalArticle

Emitter coupled logic circuits
myeloid leukemia
methyltransferases
Myeloid Cells
interferons
26 Citations (Scopus)

Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation

Shawish, H. B., Wong, W. Y., Wong, Y. L., Loh, S. W., Looi, C. Y., Hassandarvish, P., Phan, A. Y. L., Wong, W. F., Wang, H., Paterson, I. C., Ea, C. K., Mustafa, M. R. & Maah, M. J., Jun 30 2014, In : PLoS One. 9, 6, e100933.

Research output: Contribution to journalArticle

Thiosemicarbazones
transcriptional activation
Nickel
anti-inflammatory activity
nickel
2012
13 Citations (Scopus)

EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression

Ea, C. K., Hao, S. L., Yeo, K. S. & Baltimore, D., Sep 7 2012, In : Journal of Biological Chemistry. 287, 37, p. 31207-31217 11 p.

Research output: Contribution to journalArticle

Gene expression
Genes
Gene Expression
Interferon Type I
Methylation
168 Citations (Scopus)

miR-146a controls the resolution of T cell responses in mice

Yang, L., Boldin, M. P., Yu, Y., Liu, C. S., Ea, C. K., Ramakrishnan, P., Taganov, K. D., Zhao, J. L. & Baltimore, D., Aug 1 2012, In : Journal of Experimental Medicine. 209, 9, p. 1655-1670 16 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
TNF Receptor-Associated Factor 6
Transducers
MicroRNAs
2009
148 Citations (Scopus)

Regulation of NF-κB activity through lysine monomethylation of p65

Ea, C. K. & Baltimore, D., Nov 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 45, p. 18972-18977 6 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Methyltransferases
Post Translational Protein Processing
Interleukin-1
2007
46 Citations (Scopus)

Ubiquitination and TRAF signaling

Pineda, G., Ea, C. K. & Chen, Z. J., 2007, In : Advances in Experimental Medicine and Biology. 597, p. 80-92 13 p.

Research output: Contribution to journalArticle

2006
661 Citations (Scopus)

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. & Chen, Z. J., Apr 21 2006, In : Molecular Cell. 22, 2, p. 245-257 13 p.

Research output: Contribution to journalArticle

Polyubiquitin
Receptor-Interacting Protein Serine-Threonine Kinases
Ubiquitination
Protein Kinases
Tumor Necrosis Factor-alpha
2005
1835 Citations (Scopus)

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J., Sep 9 2005, In : Cell. 122, 5, p. 669-682 14 p.

Research output: Contribution to journalArticle

Antiviral Agents
Proteins
Chemical activation
Mitochondria
Virus Diseases
2004
598 Citations (Scopus)

TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains

Kanayama, A., Seth, R. B., Sun, L., Ea, C. K., Hong, M., Shaito, A., Chiu, Y. H., Deng, L. & Chen, Z. J., Aug 27 2004, In : Molecular Cell. 15, 4, p. 535-548 14 p.

Research output: Contribution to journalArticle

Polyubiquitin
Zinc Fingers
Ubiquitin
Lysine
TNF Receptor-Associated Factor 6
507 Citations (Scopus)

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Sun, L., Deng, L., Ea, C. K., Xia, Z. P. & Chen, Z. J., May 7 2004, In : Molecular Cell. 14, 3, p. 289-301 13 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Ligases
Ubiquitin
Phosphotransferases
T-Lymphocytes
83 Citations (Scopus)

TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6

Ea, C. K., Sun, L., Inoue, J. I. & Chen, Z. J., Oct 26 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 43, p. 15318-15323 6 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Ubiquitination
Phosphotransferases
Ubiquitin
Ligases
2002
116 Citations (Scopus)

Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NFκB activation

Yeh, P. Y., Chuang, S. E., Yeh, K. H., Song, Y. C., Ea, C. K. & Cheng, A. L., Apr 15 2002, In : Biochemical Pharmacology. 63, 8, p. 1423-1430 8 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Cisplatin
Transcription Factors
Chemical activation